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International Journal of Breast Cancer
Volume 2014 (2014), Article ID 423059, 7 pages
http://dx.doi.org/10.1155/2014/423059
Research Article

Comparison of Cantharidin Toxicity in Breast Cancer Cells to Two Common Chemotherapeutics

Department of Biology, Millikin University, Decatur, IL 62522, USA

Received 16 July 2014; Accepted 5 September 2014; Published 14 September 2014

Academic Editor: Ian S. Fentiman

Copyright © 2014 Katie M. Kern and Jennifer R. Schroeder. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. S. C. S. W. Group, “United states cancer statistics: 1999–2010 incidence and mortality web-based report,” Tech. Rep., U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, Atlanta, Ga, USA, 2013. View at Google Scholar
  2. J. Brollo, G. Curigliano, D. Disalvatore et al., “Adjuvant trastuzumab in elderly with HER-2 positive breast cancer: a systematic review of randomized controlled trials,” Cancer Treatment Reviews, vol. 39, no. 1, pp. 44–50, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. M. J. Higgins and J. Baselga, “Targeted therapies for breast cancer,” Journal of Clinical Investigation, vol. 121, no. 10, pp. 3797–3803, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. B. D. Lehmann, J. A. Bauer, X. Chen et al., “Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies,” Journal of Clinical Investigation, vol. 121, no. 7, pp. 2750–2767, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. C. K. Osborne, P. Neven, L. Y. Dirix et al., “Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study,” Clinical Cancer Research, vol. 17, no. 5, pp. 1147–1159, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. O'Shaughnessy, C. Osborne, J. E. Pippen et al., “Iniparib plus chemotherapy in metastatic triple-negative breast cancer,” The New England Journal of Medicine, vol. 364, no. 3, pp. 205–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Ribi, J. Aldridge, K.-A. Phillips et al., “Subjective cognitive complaints one year after ceasing adjuvant endocrine treatment for early-stage breast cancer,” The British Journal of Cancer, vol. 106, no. 10, pp. 1618–1625, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Pang, L. Cai, Y. Yang, X. Chen, G. Sui, and C. Zhao, “Knockdown of osteopontin chemosensitizes MDA-MB-231 cells to cyclophosphamide by enhancing apoptosis through activating p38 MAPK pathway,” Cancer Biotherapy and Radiopharmaceuticals, vol. 26, no. 2, pp. 165–173, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Padmanabhan, A. Howell, and R. D. Rubens, “Mechanism of action of adjuvant chemotherapy in early breast cancer,” The Lancet, vol. 2, no. 8504, pp. 411–414, 1986. View at Google Scholar · View at Scopus
  10. M. A. Richards, S. M. O'Reilly, A. Howell et al., “Adjuvant cyclophosphamide, methotrexate, and fluorouracil in patients with axillary node-positive breast cancer: an update of the Guy's/Manchester trial,” Journal of Clinical Oncology, vol. 8, no. 12, pp. 2032–2039, 1990. View at Google Scholar · View at Scopus
  11. S. B. Horwitz, “Taxol (paclitaxel): mechanisms of action,” Annals of Oncology, vol. 5, supplement 6, pp. S3–S6, 1994. View at Google Scholar · View at Scopus
  12. I. V. Subramanian, S. Devineni, R. Ghebre et al., “AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer,” Gene Therapy, vol. 18, no. 2, pp. 145–154, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. E. K. Rowinsky and R. C. Donehower, “Paclitaxel (taxol),” The New England Journal of Medicine, vol. 332, no. 15, pp. 1004–1014, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. W. E. Evans and H. L. McLeod, “Pharmacogenomics—drug disposition, drug targets, and side effects,” The New England Journal of Medicine, vol. 348, no. 6, pp. 538–549, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. C. L. Shapiro and A. Recht, “Side effects of adjuvant treatment of breast cancer,” The New England Journal of Medicine, vol. 344, no. 26, pp. 1997–2008, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. C. H. Wu, C. H. Yang, J. N. Lee, S. C. Hsu, and E. M. Tsai, “Weekly and monthly regimens of paclitaxel and carboplatin in the management of advanced ovarian cancer. A preliminary report on side effects,” International Journal of Gynecological Cancer, vol. 11, no. 4, pp. 295–299, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Sitzia and L. Huggins, “Side effects of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy for breast cancer,” Cancer Practice, vol. 6, no. 1, pp. 13–21, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Cella, M. Wang, L. Wagner, and K. Miller, “Survival-adjusted health-related quality of life (HRQL) among patients with metastatic breast cancer receiving paclitaxel plus bevacizumab versus paclitaxel alone: results from eastern cooperative oncology group study 2100 (E2100),” Breast Cancer Research and Treatment, vol. 130, no. 3, pp. 855–861, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Iwamoto, “Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs,” Biological and Pharmaceutical Bulletin, vol. 36, no. 5, pp. 715–718, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Andre, C. Hatzis, K. Anderson et al., “Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer,” Clinical Cancer Research, vol. 13, no. 7, pp. 2061–2067, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Giannakakou, D. L. Sackett, Y.-K. Kang et al., “Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization,” The Journal of Biological Chemistry, vol. 272, no. 27, pp. 17118–17125, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Yu, B. Liu, T. Jing et al., “Overexpression of both p185(c-erbB2) and p170(mdr-1) renders breast cancer cells highly resistant to taxol,” Oncogene, vol. 16, no. 16, pp. 2087–2094, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. J. S. Till and B. N. Majmudar, “Cantharidin poisoning,” Southern Medical Journal, vol. 74, no. 4, pp. 444–447, 1981. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Rauh, S. Kahl, H. Boechzelt, R. Bauer, B. Kaina, and T. Efferth, “Molecular biology of cantharidin in cancer cells,” Chinese Medicine, vol. 2, article 8, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. Y.-M. Li and J. E. Casida, “Cantharidin-binding protein: identification as protein phosphatase 2A,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 24, pp. 11867–11870, 1992. View at Publisher · View at Google Scholar · View at Scopus
  26. J.-H. Kuo, Y.-L. Chu, J.-S. Yang et al., “Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways,” International Journal of Oncology, vol. 37, no. 5, pp. 1243–1250, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. W. W. Huang, S. W. Ko, H. Y. Tsai et al., “Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways,” International Journal of Oncology, vol. 38, no. 4, pp. 1067–1073, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. W. Li, L. Xie, Z. Chen et al., “Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis,” Cancer Science, vol. 101, no. 5, pp. 1226–1233, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. G.-S. Wang, “Medical uses of mylabris in ancient China and recent studies,” Journal of Ethnopharmacology, vol. 26, no. 2, pp. 147–162, 1989. View at Publisher · View at Google Scholar · View at Scopus
  30. C.-C. Wang, C.-H. Wu, K.-J. Hsieh, K.-Y. Yen, and L.-L. Yang, “Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells,” Toxicology, vol. 147, no. 2, pp. 77–87, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Sandroni, “Aphrodisiacs past and present: a historical review,” Clinical Autonomic Research, vol. 11, no. 5, pp. 303–307, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. D. J. Karras, S. E. Farrell, R. A. Harrigan, F. M. Henretig, and L. Gealt, “Poisoning from “spanish fly” (cantharidin),” The American Journal of Emergency Medicine, vol. 14, no. 5, pp. 478–483, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Sargent and C. G. Taylor, “Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia,” British Journal of Cancer, vol. 60, no. 2, pp. 206–210, 1989. View at Publisher · View at Google Scholar · View at Scopus
  34. K. M. Huttunen, H. Raunio, and J. Rautio, “Prodrugs-from serendipity to rational design,” Pharmacological Reviews, vol. 63, no. 3, pp. 750–771, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. R. M. Pratt and W. D. Willis, “In vitro screening assay for teratogens using growth inhibition of human embryonic cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 82, no. 17, pp. 5791–5794, 1985. View at Publisher · View at Google Scholar · View at Scopus
  36. M. R. Haq, S. Ashraf, C. P. Malik, A. A. Ganie, and U. Shandilya, “In vitro cytotoxicity of Parthenium hysterophorus extracts against human cancerous cell lines,” Journal of Chemical and Pharmaceutical Research, vol. 3, no. 6, pp. 601–608, 2011. View at Google Scholar · View at Scopus
  37. J. L. Cohen and J. Y. Jao, “Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.,” Journal of Pharmacology and Experimental Therapeutics, vol. 174, no. 2, pp. 206–210, 1970. View at Google Scholar · View at Scopus
  38. H. R. Franke, S. Kole, Z. Ciftci, C. Haanen, and I. Vermes, “In vitro effects of estradiol, dydrogesterone, tamoxifen and cyclophosphamide on proliferation vs. death in human breast cancer cells,” Cancer Letters, vol. 190, no. 1, pp. 113–118, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. I. C. Henderson, D. A. Berry, G. D. Demetri et al., “Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer,” Journal of Clinical Oncology, vol. 21, no. 6, pp. 976–983, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. F. A. Holmes, R. S. Walters, R. L. Theriault et al., “Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer,” Journal of the National Cancer Institute, vol. 83, no. 24, pp. 1797–1805, 1991. View at Google Scholar · View at Scopus
  41. N. J. Robert, V. Diéras, J. Glaspy et al., “RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer,” Journal of Clinical Oncology, vol. 29, no. 10, pp. 1252–1260, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. J. L. Merlin, M. Barberi-Heyob, and N. Bachmann, “In vitro comparative evaluation of trastuzumab (Herceptin) combined with paclitaxel (Taxol) or docetaxel (Taxotere) in HER2-expressing human breast cancer cell lines,” Annals of Oncology, vol. 13, no. 11, pp. 1743–1748, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Nakayama, Y. Torikoshi, T. Takahashi et al., “Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells,” Breast Cancer Research, vol. 11, no. 1, article R12, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. D. Lai, K. C. Ho, Y. Hao, and X. Yang, “Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF,” Cancer Research, vol. 71, no. 7, pp. 2728–2738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. F. Lovat, H. Ishii, M. Schiappacassi et al., “LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer,” Oncotarget, vol. 5, no. 4, pp. 970–977, 2014. View at Google Scholar · View at Scopus
  46. X.-X. Wang, Z. Zhu, D. Su et al., “Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma,” Human Pathology, vol. 42, no. 10, pp. 1410–1419, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. J. A. Sakoff, S. P. Ackland, M. L. Baldwin, M. A. Keane, and A. McCluskey, “Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues,” Investigational New Drugs, vol. 20, no. 1, pp. 1–11, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. J. A. Sakoff and A. McCluskey, “Protein phosphatase inhibition: structure based design. Towards new therapeutic agents,” Current Pharmaceutical Design, vol. 10, no. 10, pp. 1139–1159, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. C.-C. Chang, D.-Z. Liu, S.-Y. Lin et al., “Liposome encapsulation reduces cantharidin toxicity,” Food and Chemical Toxicology, vol. 46, no. 9, pp. 3116–3121, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. L. P. Deng, J. Dong, H. Cai, and W. Wang, “Cantharidin as an antitumor agent: a retrospective review,” Current Medicinal Chemistry, vol. 20, no. 2, pp. 159–166, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. Y.-P. Zhan, X.-E. Huang, J. Cao et al., “Clinical study on safety and efficacy of qinin (cantharidin sodium) injection combined with chemotherapy in treating patients with gastric cancer,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 9, pp. 4773–4776, 2012. View at Publisher · View at Google Scholar · View at Scopus
  52. S. B. Prasad and A. K. Verma, “Cantharidin-mediated ultrastructural and biochemical changes in mitochondria lead to apoptosis and necrosis in murine dalton's lymphoma,” Microscopy and Microanalysis, vol. 19, no. 6, pp. 1377–1394, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. P. K. Jain, I. H. ElSayed, and M. A. El-Sayed, “Au nanoparticles target cancer,” Nano Today, vol. 2, no. 1, pp. 18–29, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. G. Unak, F. Ozkaya, E. Ilker Medine et al., “Gold nanoparticle probes: design and in vitro applications in cancer cell culture,” Colloids and Surfaces B: Biointerfaces, vol. 90, no. 1, pp. 217–226, 2012. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Alexiou, R. J. Schmid, R. Jurgons et al., “Targeting cancer cells: magnetic nanoparticles as drug carriers,” European Biophysics Journal, vol. 35, no. 5, pp. 446–450, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. W. Han, S. Wang, R. Liang et al., “Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin,” International Journal of Nanomedicine, vol. 8, pp. 2187–2196, 2013. View at Publisher · View at Google Scholar · View at Scopus