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International Journal of Breast Cancer
Volume 2014, Article ID 564308, 3 pages
Research Article

Prevalence of HER-2 and Hormone Receptors and P53 Mutations in the Pathologic Specimens of Breast Cancer Patients

1Department of Surgery, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
2International Azad University of Kish, Kish, Iran
3Students’ Research Committee, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

Received 20 May 2014; Accepted 24 October 2014; Published 12 November 2014

Academic Editor: Vladimir F. Semiglazov

Copyright © 2014 Seyed Abbas Mirmalek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Prognostic factors are in interest for breast cancer as the second cause of malignancy deaths. Some have predictive values as human epidermal growth factor receptor-2 (HER-2) and estrogen receptor (ER). To access the incidence of HER2 and its relations to other factors, like age, pathology, ER, progesterone receptor (PR), and P53, 2000 pathologic blocks from 2750 total samples have been selected from 2011 to 2013 in Cancer Institute of Tehran. Incidence of HER2, ER, PR, and P53 was; 58.5%, 33.4%, 43.3%, and 65.4%, respectively. Invasive ductal carcinoma was the most pathologic type (82.2%) and 60%–70% positive HER2 and P53 had negative ER and PR (poor prognosis). The peak age of incidence of breast cancer was perimenopausal age group (46–55 years). Our cases had more positive HER2 and P53 and less positive PR and ER compared to other studies. High perimenopausal incidence as another finding assures the importance of breast cancer screening in these age groups.