Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features
Table 3
Correlation between the three different histopathological features included in the definition of breast cancer with neoductgenesis in 74 cases with intermediate (grade 2) or high (grade 3) DCIS grade, with or without an invasive component.
Characteristics
Nuclear grade 3
Malignant calcifications
ER+
PR+
HER2+
Ki67 high
Tenascin-C+
Number (%)
value
Number (%)
value
Number (%)
value
Number (%)
value
Number (%)
value
Number (%)
value
Number (%)
value
Concentration of duct-like structures*
No ()
8 (47.1)
0.18
7 (41.2)
0.07
14 (87.5)
0.01
9 (56.2)
0.2
6 (37.5)
0.04
6 (37.5)
0.6
7 (77.8)
0.45
Focal ()
22 (66.7)
24 (72.7)
28 (84.8)
23 (69.7)
9 (29.0)
8 (25.8)
18 (72.0)
General ()
18 (75.0)
17 (70.8)
11 (50.0)
10 (45.5)
14 (63.6)
8 (36.4)
15 (88.2)
Lymphocytic infiltration*
No ()
13 (50.0)
0.02
13 (50.0)
0.06
23 (92.0)
0.001
22 (88.0)
0.0002
1 (4.2)
<0.00001
6 (25.0)
0.46
11 (78.6)
0.19
Mild ()
18 (62.1)
19 (65.5)
23 (79.3)
15 (51.7)
14 (48.3)
9 (31.0)
15 (68.2)
Intense ()
17 (89.5)
16 (84.2)
7 (41.1)
5 (29.4)
14 (87.5)
7 (43.8)
14 (93.3)
Fibrosis-like thickening of the periductal stroma*
No ()
4 (50.0)
0.16
5 (62.5)
0.04
6 (85.7)
<0.001
6 (85.7)
0.04
1 (14.3)
0.0001
2 (28.6)
0.20
3 (75.0)
0.70
Mild ()
32 (61.5)
30 (57.7)
43 (84.3)
32 (62.7)
17 (34.7)
13 (26.5)
29 (76.3)
Intense ()
12 (85.7)
13 (92.9)
4 (7.7)
4 (30.8)
12 (92.3)
7 (53.8)
8 (88.9)
*The scores are based on the mean value between the four different pathologists.
