Table of Contents Author Guidelines Submit a Manuscript
International Journal of Breast Cancer
Volume 2014 (2014), Article ID 627352, 6 pages
http://dx.doi.org/10.1155/2014/627352
Clinical Study

Early Invasive Cancer and Partial Intraoperative Electron Radiation Therapy of the Breast: Experience of the Jules Bordet Institute

1Department of Radiation Oncology, Jules Bordet Institute, 1000 Brussels, Belgium
2Department of Radiophysics, Jules Bordet Institute, 1000 Brussels, Belgium
3Department of Surgery, Jules Bordet Institute, 1000 Brussels, Belgium
4Department of Pathology, Jules Bordet Institute, 1000 Brussels, Belgium
5Department of Nuclear Medicine, Jules Bordet Institute, 1000 Brussels, Belgium

Received 14 February 2014; Revised 26 April 2014; Accepted 12 May 2014; Published 9 June 2014

Academic Editor: Felix Sedlmayer

Copyright © 2014 C. Philippson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. Veronesi, N. Cascinelli, L. Mariani et al., “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” The New England Journal of Medicine, vol. 347, no. 16, pp. 1227–1232, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Fisher, S. Anderson, J. Bryant et al., “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” The New England Journal of Medicine, vol. 347, no. 16, pp. 1233–1241, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Bartelink, J.-C. Horiot, P. M. Poortmans et al., “Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial,” Journal of Clinical Oncology, vol. 25, no. 22, pp. 3259–3265, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Van Limbergen, W. Van den Bogaert, E. Van der Schueren, and A. Rijnders, “Tumor excision and radiotherapy as primary treatment of breast cancer. Analysis of patient and treatment parameters and local control,” Radiotherapy and Oncology, vol. 8, no. 1, pp. 1–9, 1987. View at Google Scholar · View at Scopus
  5. T. E. Smith, D. Lee, B. C. Turner, D. Carter, and B. G. Haffty, “True recurrence vs. new primary ipsilateral breast tumor relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management,” International Journal of Radiation Oncology, Biology, Physics, vol. 48, no. 5, pp. 1281–1289, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. B. G. Haffty, D. Carter, S. D. Flynn et al., “Local recurrence versus new primary: clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting,” International Journal of Radiation Oncology, Biology, Physics, vol. 27, no. 3, pp. 575–583, 1993. View at Google Scholar · View at Scopus
  7. E. Huang, T. A. Buchholz, F. Meric et al., “Classifying local disease recurrences after breast conservation therapy based on location and histology: new primary tumors have more favorable outcomes than true local disease recurrences,” Cancer, vol. 95, no. 10, pp. 2059–2067, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. T. J. Whelan, J.-P. Pignol, M. N. Levine et al., “Long-term results of hypofractionated radiation therapy for breast cancer,” The New England Journal of Medicine, vol. 362, no. 6, pp. 513–520, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Bentzen, R. K. Agrawal, E. G. Aird et al., “The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial,” The Lancet, vol. 371, no. 9618, pp. 1098–1107, 2008. View at Google Scholar
  10. Y. M. Kirova, F. Campana, A. Savignoni et al., “Breast-conserving treatment in the elderly: long-term results of adjuvant hypofractionated and normofractionated radiotherapy,” International Journal of Radiation Oncology, Biology, Physics, vol. 75, no. 1, pp. 76–81, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. B. D. Smith, D. W. Arthur, T. A. Buchholz et al., “Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO),” International Journal of Radiation Oncology, Biology, Physics, vol. 74, no. 4, pp. 987–1001, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Polgár, E. V. Limbergen, R. Pötter et al., “Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009),” Radiotherapy and Oncology, vol. 94, no. 3, pp. 264–273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Philippson and J. M. Nogaret, “Cancer du sein et radiothérapie peropératoire par électrons (IOERT),” EMC-Gynécologie Obstétrique, vol. 7, no. 4, pp. 1–8, 2012. View at Publisher · View at Google Scholar
  14. E. S. Stovgaard, T. F. Tvedskov, A. V. Lænkholm, and E. Balslev, “Cytokeratin on frozen sections of sentinel node may spare breast cancer patients secondary axillary surgery,” Pathology Research International, vol. 2012, Article ID 802184, 5 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. U. Veronesi, R. Orecchia, A. Luini et al., “Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery: experience with 590 cases,” Annals of Surgery, vol. 242, no. 1, pp. 101–106, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Sotiriou, P. Wirapati, S. Loi et al., “Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis,” Journal of the National Cancer Institute, vol. 98, no. 4, pp. 262–272, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Trotti, A. D. Colevas, A. Setser et al., “CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment,” Seminars in Radiation Oncology, vol. 13, no. 3, pp. 176–181, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. “LENT SOMA scales for all anatomic sites,” International Journal of Radiation Oncology, Biology, Physics, vol. 31, no. 5, pp. 1049–1091, 1995.
  19. K. Beal, B. McCormick, M. J. Zelefsky et al., “Single-fraction intraoperative radiotherapy for breast cancer: early cosmetic results,” International Journal of Radiation Oncology, Biology, Physics, vol. 69, no. 1, pp. 19–24, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Holland, J. L. Connolly, R. Gelman et al., “The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast,” Journal of Clinical Oncology, vol. 8, no. 1, pp. 113–118, 1990. View at Google Scholar · View at Scopus
  21. M. Overgaard, H. M. Nielsen, and J. Overgaard, “Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials,” Radiotherapy and Oncology, vol. 82, no. 3, pp. 247–253, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. O. Nairz, H. Deutschmann, M. Kopp et al., “A dosimetric comparison of IORT techniques in limited-stage breast cancer,” Strahlentherapie und Onkologie, vol. 182, no. 6, pp. 342–348, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. U. Veronesi, R. Orecchia, P. Maisonneuve et al., “Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial,” The Lancet Oncology, vol. 14, no. 13, pp. 1269–1277, 2013. View at Google Scholar
  24. B. G. Haffty, Q. Yang, M. Reiss et al., “Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer,” Journal of Clinical Oncology, vol. 24, no. 36, pp. 5652–5657, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Vaidya, F. Wenz, M. Bulsara et al., “Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial,” The Lancet Oncology, vol. 383, pp. 603–613, 2014. View at Google Scholar
  26. S. Aebi, T. Davidson, G. Gruber, and F. Cardoso, “Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 22, no. 6, pp. vi12–vi24, 2011. View at Publisher · View at Google Scholar · View at Scopus