The Value of Intraoperative Frozen Section Analysis for Margin Status in Breast Conservation Surgery in a Nontertiary Institution

Table 1

Summary of demographic, clinicopathologic, and outcome data for study population.

Clinicopathologic characteristic	All patients (%)		BCT (%)	Mastectomy (%)	value
Age in years
Median (range)	48 (28–78)
Mean (SD)	48.8 (9.8)		48.3 (10)	52.4 (8.3)	0.04
Ethnicity					0.87
Chinese	106	(65.8)	91	15
Malay/Indonesian	11	(6.8)	9	2
Indian	12	(7.5)	11	1
Other Asian	14	(8.7)	13	1
Caucasian	18	(11.2)	14	4
Mode of presentation					0.02
Symptomatic tumours	116	(72)	95	21
Screen detected lesions	45	(28)	43	2
All patients	161		138 (85.7%)	23 (14.3%)
				By need 15 (9.3%)
				By choice 8 (5.0%)
Tumour size in mm (range)
Median (range)	19.0 (4–97)
Mean (SD)	21.6		19.7 (12.4)	33.0 (26.0)	<0.001
T1	100	(62.1)	92	8
T2	50	(31.1)	39	11
T3	8	(5.0)	5	3
T4	3	(1.8)	2	1
Stage at diagnosis					<0.001
0	20	(12.4)	18	2
I	67	(41.6)	66	1
II	55	(34.2)	46	9
III	18	(11.2)	8	10
IV	1	(0.6)	0	1
Histological type					0.39
DCIS	20	(12.4)	18	2
Invasive ductal	125	(77.6)	108	17
Invasive lobular	7	(4.4)	5	2
Other invasive	9	(5.6)	7	2
Neoadjuvant medical therapy
Yes	23	(14.3)	14	9
No	138	(85.7)	124	7
Disease extent					0.06
Unifocal	121	(75.2)	104	17
Multiple foci at diagnosis	40	(24.8)	34	4
Recurrence					0.26
Local recurrence	3	(1.9)	2 (1.4%)	1 (4.3%)
Distant disease/death	4	(2.5)	2 (1.4%)	2 (8.7%)
Median follow-up (months)	45
(range)	(18–64)

BCT: breast conservation surgery; SD: standard deviation.
DCIS: ductal carcinoma in situ.