Clinical Study
The Value of Intraoperative Frozen Section Analysis for Margin Status in Breast Conservation Surgery in a Nontertiary Institution
Table 1
Summary of demographic, clinicopathologic, and outcome data for study population.
| Clinicopathologic characteristic | All patients (%) | BCT (%) | Mastectomy (%) | value |
| Age in years | | | | | | Median (range) | 48 (28–78) | | | | | Mean (SD) | 48.8 (9.8) | | 48.3 (10) | 52.4 (8.3) | 0.04 | Ethnicity | | | | | 0.87 | Chinese | 106 | (65.8) | 91 | 15 | | Malay/Indonesian | 11 | (6.8) | 9 | 2 | | Indian | 12 | (7.5) | 11 | 1 | | Other Asian | 14 | (8.7) | 13 | 1 | | Caucasian | 18 | (11.2) | 14 | 4 | | Mode of presentation | | | | | 0.02 | Symptomatic tumours | 116 | (72) | 95 | 21 | | Screen detected lesions | 45 | (28) | 43 | 2 | | All patients | 161 | | 138 (85.7%) | 23 (14.3%) | | By need 15 (9.3%) | | By choice 8 (5.0%) | Tumour size in mm (range) | | | | | | Median (range) | 19.0 (4–97) | | | | | Mean (SD) | 21.6 | | 19.7 (12.4) | 33.0 (26.0) | <0.001 | T1 | 100 | (62.1) | 92 | 8 | | T2 | 50 | (31.1) | 39 | 11 | | T3 | 8 | (5.0) | 5 | 3 | | T4 | 3 | (1.8) | 2 | 1 | | Stage at diagnosis | | | | | <0.001 | 0 | 20 | (12.4) | 18 | 2 | | I | 67 | (41.6) | 66 | 1 | | II | 55 | (34.2) | 46 | 9 | | III | 18 | (11.2) | 8 | 10 | | IV | 1 | (0.6) | 0 | 1 | | Histological type | | | | | 0.39 | DCIS | 20 | (12.4) | 18 | 2 | | Invasive ductal | 125 | (77.6) | 108 | 17 | | Invasive lobular | 7 | (4.4) | 5 | 2 | | Other invasive | 9 | (5.6) | 7 | 2 | | Neoadjuvant medical therapy | | | | | | Yes | 23 | (14.3) | 14 | 9 | | No | 138 | (85.7) | 124 | 7 | | Disease extent | | | | | 0.06 | Unifocal | 121 | (75.2) | 104 | 17 | | Multiple foci at diagnosis | 40 | (24.8) | 34 | 4 | | Recurrence | | | | | 0.26 | Local recurrence | 3 | (1.9) | 2 (1.4%) | 1 (4.3%) | | Distant disease/death | 4 | (2.5) | 2 (1.4%) | 2 (8.7%) | | Median follow-up (months) | 45 | | | | | (range) | (18–64) | | | | |
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BCT: breast conservation surgery; SD: standard deviation. DCIS: ductal carcinoma in situ.
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