Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm
Table 5
Multivariate analysis model estimates for percent breast density (%-G), fibroglandular tissue volume (GV), fat tissue volume (FV), and total breast volume (TV) measured by five different methods ().
Explanatory variable
Standardized -estimates (SE)
%-G
GV
FV
TV
BMI
−0.62 (0.02)***
0.03 (0.03)
0.79 (0.02)***
0.71 (0.02)***
Age
−0.03 (0.2)
−0.01 (0.02)
−0.02 (0.02)
−0.02 (0.02)
Age at menarche
0.03 (0.2)
0.03 (0.02)
0.01 (0.02)
0.02 (0.02)
Pregnancy, completed
Zero
Reference
One
−0.08 (0.08)
−0.002 (0.1)
0.18 (0.07)*
0.16 (0.07)*
Two
−0.24 (0.07)**
−0.37 (0.08)***
0.005 (0.06)
−0.14 (0.06)*
Three and more
−0.41 (0.07)***
−0.69 (0.08)***
−0.12 (0.06)*
−0.35 (0.06)***
Measurement methoda,b
HSM
Reference
GE
−0.003 (0.06)
−0.01 (0.07)
0.002 (0.05)
0 (0.05)
MATH
0.01 (0.06)
0.01 (0.07)
0.001 (0.05)
0 (0.05)
3DGRE
0.002 (0.06)
−0.003 (0.07)
0.003 (0.05)
0 (0.06)
STIR
0.03 (0.06)
0.01 (0.08)
−0.02 (0.05)
−0.02 (0.06)
Race and ethnicity
Non-Hispanic White race
Reference
Hispanic race
0.16 (0.05)**
0.33 (0.06)***
−0.12 (0.04)**
0.01 (0.04)
African-American race
0.47 (0.06)***
0.39 (0.08)***
−0.22 (0.05)***
−0.05 (0.06)
Model
0.38
0.09
0.58
0.51
HSM, histogram segmentation method; FFDM, full field digital mammography unit; MATH, mathematical algorithm; 3DGRE, 3D gradient echo; STIR, short tau inversion recovery.
bInteraction terms between predictors and measurement methods were all not significant (results not shown). , , and .
