Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer

Table 1

Patient characteristics.

			Index of undetected comorbidity
	Overall		Score
	(𝑛 = 61,002)		0		≥1		𝑃 value
	𝑛	%	(𝑛 = 54,818)		(𝑛 = 6,184)
			𝑛	%	𝑛	%
Age at cancer diagnosis (years)
66–70	12,361	20.3	11,412	20.8	949	15.4	<0.0001
71–75	15,368	25.2	14,036	25.6	1,332	21.5
76–80	15,108	24.8	13,576	24.8	1,532	24.8
>80	18,165	29.8	15,794	28.8	2,371	38.3
Race/ethnicity
White	52,270	85.7	47,048	85.8	5,222	84.4	<0.0001
Black	4,188	6.9	3,639	6.6	549	8.9
Hispanic	2,249	3.7	2,016	3.7	233	3.8
Other	2,295	3.8	2,115	3.9	180	2.9
Year of cancer diagnosis
2001	12,660	20.8	11,322	20.7	1,338	21.6	0.12
2002	12,452	20.4	11,166	20.4	1,286	20.8
2003	12,086	19.8	10,845	19.8	1,241	20.1
2004	11,929	19.6	10,765	19.6	1164	18.8
2005	11,875	19.5	10,720	19.6	1155	18.7
Index of prior comorbidity score; (NCI Comorbidity Index)
0	41,001	67.2	37,365	68.2	3,636	58.8	<0.0001
1	13,480	22.1	11,952	21.8	1,528	24.7
≥2	6,521	10.7	5,501	10.0	1020	16.5
Stage at diagnosis
𝐼𝑛  𝑠𝑖𝑡𝑢	10,167	16.7	9,618	17.6	549	8.8	<0.0001
I	26,754	43.9	24,578	44.8	2,176	35.1
II	17,165	28.1	15,080	27.5	2,085	33.7
III	4,096	6.7	3,428	6.3	668	10.8
IV	2,820	4.6	2,114	3.9	706	11.4
Estrogen (ER) and progesterone (PR) receptor status
ER and PR positive	31,419	51.5	28,347	51.7	3,072	49.7	<0.0001
ER or PR positive	8,081	13.3	7,203	13.1	878	14.2
ER and PR negative	7,165	11.8	6,353	11.6	812	13.1
Unknown/missing	14,337	23.5	12,915	23.6	1,422	23.0
Histological grade
1	12,419	20.4	11,403	20.8	1,016	16.4	<0.0001
2	23,407	38.4	21,090	38.5	2,317	37.5
3	15,291	25.1	13,528	24.7	1,763	28.5
4	1,881	3.1	1,710	3.1	171	2.8
Missing/unknown	8,004	13.1	7,087	12.9	917	14.8
Indicators of poor performance
0	52,460	86.0	47,599	86.8	4,861	78.6	<0.0001
≥1	8,542	14.0	7,219	13.2	1,323	21.4
Percent in census tract with some college
<25%	21,117	34.6	18,822	34.4	2,295	37.1	<0.0001
≥25%	39,885	65.4	35,996	65.7	3,889	62.9
Percent in census tract living in poverty
<5%	19,951	32.7	18,276	33.3	1,675	27.1	<0.0001
5–7%	8,718	14.3	7,919	14.5	799	12.9
8–12%	13,566	22.2	12,177	22.2	1,389	22.5
>12%	18,767	30.8	16,446	30.0	2,321	37.5
Type of geographic area
Large metropolitan	34,481	56.5	31,090	56.7	3,391	54.8	<0.0001
Metropolitan	17,568	28.8	15,840	28.9	1,728	27.9
Urban	3,674	6.0	3,242	5.9	432	7.0
Less urban/rural	5,279	8.7	4,646	8.5	633	10.2