Associations between Reoperations and Psychological Factors after Contralateral Risk-Reducing Mastectomy: A Two-Year Follow-Up Study
Table 1
Demographic and clinical data for all eligible patients according to reoperation after CRRM ().
Variable
No reoperation (%)
Reoperation (%)
value
Age at CPM, years
25–35
5 (13.9)
7 (15.9)
0.85
35–45
13 (36.1)
19 (43.2)
45–55
11 (30.6)
12 (27.3)
55–65
7 (19.4)
6 (13.7)
BRCA mutation status
BRCA1
16 (44.4)
18 (40.9)
0.14
BRCA2
7 (19.5)
2 (4.6)
BRCAX
9 (25.0)
17 (38.6)
No mutation or unknown
4 (11.1)
7 (15.9)
Prophylactic salpingo-oophorectomy
Yes
20 (55.6)
16 (36.4)
0.09
No
16 (44.4)
28 (63.6)
Primary tumor size
Tis
4 (11.1)
2 (4.6)
0.61
T1
18 (50.0)
25 (56.8)
T2
10 (27.8)
14 (31.8)
T3
4 (11.1)
3 (6.8)
Lymph nodes
N+
18 (50.0)
23 (52.3)
0.84
N0
18 (50.0)
21 (47.8)
Radiotherapy
Yes
20 (56.6)
37 (84.1)
0.005
No
16 (44.4)
7 (15.9)
Chemotherapy
Yes
19 (52.8)
33 (75.0)
0.038
No
17 (47.2)
11 (25.0)
Endocrine therapy
Yes
19 (52.8)
23 (52.3)
0.96
No
17 (47.2)
21 (47.7)
Side CPM
Right
23 (63.9)
21 (47.7)
0.30
Left
13 (36.1)
21 (52.3)
Reconstruction with
Permanent implant
15 (41.7)
12 (27.3)
0.18
Expandable implant
21 (58.3)
32 (72.7)
Simultaneous operation on cancer side
Delayed reconstruction
16 (44.4)
16 (36.4)
0.59
Completion mastectomy with IBR
12 (33.4)
20 (45.5)
Implant replacement
4 (11.1)
4 (9.1)
No operation
4 (11.1)
4 (9.1)
CRRM: contralateral prophylactic mastectomy; IBR: immediate breast reconstruction. #Unanticipated surgical procedure on any breast after CRRM with breast reconstruction. Fisher’s exact test. Removal of the remaining breast after previous breast-conservative surgery. Patient screened negative for known mutations having any other case of BC onset before the age of 50 in the family. Five participants underwent prophylactic salpingo-oophorectomy after CPM. One patient underwent therapeutic mastectomy.