The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy

Figure 2

Schematic diagram of the biological role of FOXM1 in breast cancer tumorigenesis. Recent research has shown that the effects of FOXM1 on breast cancer tumorigenesis are mediated by a number of diverse biological mechanisms. EMT: epithelial-mesenchymal transition; TGF-β: transforming growth factor-beta; uPA: urokinase; uPAR: urokinase receptor; MMP-2: matrix metallopeptidase-2; MMP-9: matrix metallopeptidase-9; VEGF: vascular endothelial growth factor.