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International Journal of Breast Cancer
Volume 2017, Article ID 4537532, 6 pages
https://doi.org/10.1155/2017/4537532
Research Article

P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site

1Department of Pathology & Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
2Comprehensive Breast Program, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
3Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
4Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA

Correspondence should be addressed to Todd W. Miller; ude.htuomtrad@rellim.w.ddot

Received 17 February 2017; Accepted 7 May 2017; Published 15 June 2017

Academic Editor: Debra A. Tonetti

Copyright © 2017 Jonathan D. Marotti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. M. Blows, K. E. Driver, M. K. Schmidt et al. et al., “Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies,” PLoS Medicine, vol. 7, no. 5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Tang and G. M. Tse, “Immunohistochemical surrogates for molecular classification of breast carcinoma: A 2015 update,” Archives of Pathology and Laboratory Medicine, vol. 140, no. 8, pp. 806–814, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. American_Cancer_Society. Cancer Facts and Figures 2016. Atlanta: American Cancer Society, 2016.
  4. C. D. Savci-Heijink, H. Halfwerk, G. K. J. Hooijer, H. M. Horlings, J. Wesseling, and M. J. van de Vijver, “Retrospective analysis of metastatic behaviour of breast cancer subtypes,” Breast Cancer Research and Treatment, vol. 150, no. 3, pp. 547–557, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. L. M. Dillon, J. R. Bean, W. Yang et al., “P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer,” Oncogene, vol. 34, no. 30, pp. 3968–3976, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Ebi, C. Costa, A. C. Faber et al., “PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 52, pp. 21124–21129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. H. C. E. Welch, W. J. Coadwell, C. D. Ellson et al., “P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac,” Cell, vol. 108, no. 6, pp. 809–821, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Hernández-Negrete, J. Carretero-Ortega, H. Rosenfeldt et al., “P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration,” Journal of Biological Chemistry, vol. 282, no. 32, pp. 23708–23715, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Qin, Y. Xie, B. Wang et al., “Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis,” Oncogene, vol. 28, no. 16, pp. 1853–1863, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. C. R. Lindsay, S. Lawn, A. D. Campbell et al., “P-Rex1 is required for efficient melanoblast migration and melanoma metastasis,” Nature Communications, vol. 2, no. 1, article no. 555, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. S. Sosa, C. Lopez-Haber, C. Yang et al., “Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer,” Molecular Cell, vol. 40, no. 6, pp. 877–892, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Barrio-Real, L. G. Benedetti, N. Engel et al., “Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation,” Breast cancer research : BCR, vol. 16, no. 5, p. 441, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. J. C. Montero, S. Seoane, A. Ocãa, and A. Pandiella, “P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer,” Oncogene, vol. 30, no. 9, pp. 1059–1071, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Barrio-Real, E. Wertheimer, R. Garg, M. C. Abba, and M. G. Kazanietz, “Characterization of a P-Rex1 gene signature in breast cancer cells,” Oncotarget, vol. 7, no. 32, pp. 51335–51348, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. M. G. Kazanietz, L. Barrio-Real, V. Casado-Medrano, M. J. Baker, and C. Lopez-Haber, “The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses,” Small GTPases, pp. 1–7, 2016. View at Publisher · View at Google Scholar · View at Scopus