Association between Lymph Node Status and Expression Levels of Androgen Receptor, miR-185, miR-205, and miR-21 in Breast Cancer Subtypes

Table 3

Association of miR-205, miR-185, miR-21, and AR expression levels with clinicopathologic characteristics in subtypes of breast cancer.

Characteristics			Relative level of miRNA or mRNA and value
			miR-205	value	miR-185	value	miR-21	value	AR	value
Luminal A
T stage	T1	9	0.96	0.132	0.41	0.895	10.02	0.433	0.92	0.332
	T2	15	0.25		0.79		4.58		0.84
N stage	N0	16	0.45	0.867	0.55	0.632	7.10	0.285	0.82	0.824
	N1-N3	8	0.22		0.68		1.98		1.16
PR score	0-5	10	0.12	0.006	0.41	0.365	2.92	0.423	0.69	0.151
	6-8	14	0.91		0.99		7.51		0.86
ER score	0-5	2	0.37	0.412	1.30	0.208	14.61	0.952	0.84	0.960
	6-8	22	0.34		0.32		5.14		0.86
Ki-67 index (%)	<10	10	0.22	0.594	0.18	0.082	6.68	0.689	0.81	0.765
	≥10	14	0.34		0.99		3.60		0.85
Luminal B (HER2-negative)
T stage	T1	9	0.46	0.082	0.22	0.138	4.17	0.832	1.17	0.399
	T2-T4	11	0.17		0.68		7.43		0.78
N stage	N0	11	0.13	0.100	0.91	0.045	7.14	0.307	0.94	0.862
	N1-N2	9	0.35		0.13		2.89		0.97
PR score	0-5	11	0.17	0.022	0.90	0.033	7.28	0.637	0.74	0.010
	6-8	9	1.89		0.13		4.17		1.57
ER score	0-5	8	0.13	0.587	0.47	0.459	9.01	0.551	0.61	0.008
	6-8	12	0.23		0.14		5.01		1.47
Ki-67 index (%)	<20	10	0.14	0.958	0.19	0.452	7.14	0.916	1.41	0.810
	≥20	10	0.17		0.88		4.17		0.89
Luminal B (HER2-positive)
T stage	T1	7	0.32	0.725	1.58	0.040	20.33	0.248	0.88	0.895
	T2-T4	13	0.18		0.20		4.05		0.89
N stage	N0	8	0.08	0.008	1.03	0.036	36.07	0.045	1.17	0.036
	N1-N3	12	0.35		0.22		5.18		0.59
PR score	0-5	10	0.12	0.043	1.92	0.031	23.82	0.431	0.80	0.930
	6-8	10	0.45		0.23		12.05		0.88
ER score	0-5	4	0.16	0.585	1.50	0.845	11.79	0.585	0.76	0.764
	6-8	16	0.22		0.34		13.38		0.78
HER2 score	1	13	0.35	0.116	0.31	0.018	3.05	0.006	0.88	0.693
	2-3	7	0.15		2.50		46.55		0.88
Ki-67 index (%)	<20	9	0.18	0.927	0.24	0.262	9.29	0.525	0.80	0.653
	≥20	11	0.27		0.61		17.81		0.86
HER2-positive
T stage	T1	5	0.15	0.156	0.73	0.777	3.85	0.366	0.33	0.915
	T2-T4	8	1.01		0.21		10.17		0.26
N stage	N0	7	1.07	0.897	0.43	0.713	9.28	0.270	0.39	0.022
	N1-N3	6	0.39		0.20		5.22		0.10
HER2 score	1	5	0.18	0.167	0.27	0.167	5.53	0.915	0.12	0.362
	2-3	8	1.17		1.09		9.28		0.34
Ki-67 index (%)	<40	6	1.17	0.235	0.57	0.523	6.68	0.835	0.43	0.095
	≥40	7	0.52		0.29		7.20		0.08
Triple-negative
T stage	T1	7	0.05	0.136	0.41	0.749	12.79	0.391	0.13	0.056
	T2-T4	5	0.27		0.49		4.59		0.03
N stage	N0	9	0.13	0.171	0.24	0.362	5.02	0.868	0.13	0.820
	N1-N3	3	0.49		0.95		4.30		0.13
Ki-67 index (%)	<70	4	0.16	0.915	0.81	0.110	9.91	0.156	0.15	0.110
	≥70	8	0.17		0.20		2.62		0.05

Median of relative change of miRNA or mRNA levels in the breast tumor versus paired normal (adjoining) tissue.