Research Article

A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2– Metastatic Breast Cancer

Table 3


No.Search String

1exp breast neoplasms/ or exp breast cancer/
2(breast$ adj3 (cancer$ or neoplas$ or oncolog$ or tumo?r$ or malignanc$ or carcinoma$ or adenocarcinoma$ or sarcoma$)).ti,ab.
3(mammar$ adj3 (cancer$ or neoplas$ or oncolog$ or tumo?r$ or malignanc$ or carcinoma$ or adenocarcinoma$ or sarcoma$)).ti,ab.
4(metasta$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$).ti,ab,sh.
5(1 or 2 or 3) and 4
6exp Breast/ and exp Neoplasm Metastasis/
7(breast$ adj3 (metasta$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).ti,ab.
8(mammar$ adj3 (metasta$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).ti,ab.
9(breast$ or mammar$).ti,ab,sh.
10((stage or grade or type) adj2 ("3" or III or "c" or "4" or "IV" or d)).ti,ab.
11(N1 or N2$ or N3$ or pN1$ or pN2$ or pN3$).ti,ab,sh.
129 and (10 or 11)
13OR/5-8,12
14(Antineoplastic Agents). ti,ab,rn,kw.
15(selective estrogen receptor modulators). ti,ab,rn,kw.
16(estrogen antagonists). ti,ab,rn,kw.
17(drug therapy). ti,ab,rn,kw.
18(letrozole or Femara or CGS 20267 or CGS-20267 or 112809-51-5). ti,ab,rn,kw
19(anastrozole or Arimidex or ZD1033 or ZD-1033 or ICI D1033 or 120511-73-1). ti,ab,rn,kw.
20(exemestane or examestane or Aromasin or Aromasine or Aromasil or FCE 24304 or FCE-24304 or 107868-30-4). ti,ab,rn,kw.
21(tamoxifen or Nolvadex or Novaldex or Soltamox or Tomaxithen or Zitazonium or ICI 46474 or ICI-46474 or ICI 47699 or ICI-47699 or 10540-29-1). ti,ab,rn,kw
22(fulvestrant or Faslodex or ICI 182780 or ICI-182780 or ZM 182780 or ZM-182780 or 129453-61-8). ti,ab,rn,kw.
23(palbociclib or Ibrance or PD 0332991 or PD-0332991 or 571190-30-2). ti,ab,rn,kw.
24(everolimus or Afinitor or Certican or RAD001 or RAD 001 or SDZ RAD or SDZ-RAD or 159351-69-6).ti,ab,rn,kw.
25(LEE011 or LEE-011 or Ribociclib or 1211441-98-3). ti,ab,rn,kw.
26(abemaciclib or LY2835219 or LY2835210 or 1231929-97-7).ti,ab,rn,kw.
27(capecitabine or Xeloda or 154361-50-9).ti,ab,rn,kw.
28(doxorubicin or Adriamycin or Doxil or Adriablastin or Adriablastine or Adriblastin or Adriblastina or Adriblastine or Adrimedac or Doxolem or Doxorubicin or Doxotec or Farmiblastina or Myocet or Onkodox or Ribodoxo or Rubex 23214-92-8).ti,ab,rn,kw.
29(paclitaxel or Abraxane or Paxene or NSC-125973 or NSC125973 or Anzatax or Onxol or Praxel or Taxol or 33069-62-4).ti,ab,rn,kw.
30(docetaxel or Taxotere or Docefrez or RP 56976 or RP-56976 or 114977-28-5).ti,ab,rn,kw.
31(cyclophosphamide or cytophosphane or Cytoxan or Endoxan or NSC 26271 or B 518 or B-518 or Cyclophosphane or Cytophosphan or Neosar or Procytox or NSC-26271 or 50-18-0).ti,ab,rn,kw.
32(eribulin or Halaven or NSC 707389 or NSC-707389 or B 1793 or B 1939 or B-1793 or B-1939 or E 7389 or E-7389 or ER 086526 or ER-086526 or ER-86526 or ER086526 or eribulin or Halaven or 253128-41-5).ti,ab,rn,kw.
33(ethinyl estradiol).ti,ab,rn,kw.
34(megestrol acetate or Megace or Mestrel or Maygace or Megostat).ti,ab,rn,kw.
35(methotrexate or Amethopterin or Trexall).ti,ab,rn,kw.
36(Fluorouracil or 5FU or 5-FU or 5-Fluorouracil or 5 Fluorouracil or Fluoruracil or Adrucil or Carac or Efudix or Efudex or Fluoroplex or Flurodex or Fluracedyl).ti,ab,rn,kw.
37(toremifene or Fareston or FC-1157a or FC 1157a or FC1157a).ti,ab,rn,kw.
38(gemcitabine or Gemzar or LY 188011 or LY-188011).ti,ab,rn,kw.
39(vinorelbine or Navelbine or KW 2307 or KW-2307).ti,ab,rn,kw.
40(abraxane or Albumin Bound Paclitaxel or ABI007 or ABI-007 or ABI 007).ti,ab,rn,kw.
41(ixabepilone or azaepothilone B or BMS247550 or BMS 247550 or BMS-247550 or Ixempra).ti,ab,rn,kw.
42(cisplatin or cis-platinum or NSC-119875 or Platino or Platinol or Platidiam).ti,ab,rn,kw.
43(carboplatin or Carbosin or Carbotec or Paraplatin or Carboplat or NSC-241240 or NSC 241240 or NSC241240).ti,ab,rn,kw.
44(Fluoxymesterone or Stenox or Halotestin or fluoximesterone).ti,ab,rn,kw.
45OR/14-44
46(animals not humans).sh.
47(comment or editorial or editorial or book or practice-guideline or letter or journal correspondence).pt.
4845 not (46 or 47)
4913 and 45 and 48
50(Phosphatidylinositol 3-Kinases or “PIK3CA protein, human”)
5149 and 50
52limit 51 to english
53 4remove duplicates from 52