Research Article

In Vitro Growth Inhibition, Caspase-Dependent Apoptosis, and S and G2/M Phase Arrest in Breast Cancer Cells Induced by Fluorine-Incorporated Gold I Compound, Ph3PAu[SC(OMe)=NC6H4F-3]

Table 1

IC50 of gold (I) compounds 3F1, 3F3, and 3FL, and CDDP (cisplatin) at 24 h.

Cell linesIC50 (μM)a
3F13F33FLCDDP

MDA-MB-231>60>80
MCF-7>80>80
H9c2NANA
BCANANA
BCSC-PNANA
BCSCNANA

aConcentration of the respective compound required for 50% inhibition of cell viability determined by the MTT assay. The results are reported as the of three independent experiments.