International Journal of Breast Cancer

Breast Axillary Lymph Node Metastasis


Publishing date
01 Oct 2011
Status
Published
Submission deadline
01 Apr 2011

1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW, Washington, DC 20007, USA

2Clinical Breast Care Project, 620 Seventh Street, Windber, PA 15963, USA

3Department of Pathology, Division of Oncogenomics, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany

4Department of Pathology, European Institute of Oncology, School of Medicine , University of Milan School of Medicine, Via Ripamonti 435, 20141 Milan, Italy


Breast Axillary Lymph Node Metastasis

Description

Axillary lymph node status is the most relevant prognostic parameter in newly diagnosed breast cancer patients and a crucial component to the breast cancer staging system. Established clinical-pathological parameters have been associated with the potential risk of developing lymph node metastasis, and new information is now emerging from genomewide studies, such as gene expression microarray analysis, which has allowed the stratification of patients based on the risk of developing metastasis. However, these parameters are not sufficient; they fail to accurately predict which tumors will disseminate from their primary site, showing their inability to fully reflect the complex molecular biology of breast cancer invasion and metastasis. The continued improvement of molecular tumor profiling in combined bioinformatics from larger and better defined patient cohorts based on lymph node status, will contribute to the clarification of this complex molecular mechanisms, leading to the identification of novel and integrative molecular markers that can reliably predict lymph node involvement. Identification of such markers could influence breast cancer management, allowing for an early axillary lymph node status prediction and a personalized clinical intervention, providing newly diagnosed breast cancer patients with more suitable adjuvant treatments.

We invite authors to submit original research and review articles related to the topics of interest of this special issue. Potential topics include, but are not limited to:

  • Clinical history of lymph node: from Halstead radical mastectomy to SLN biopsy analysis
  • SLN tracing: dyes, fluorochromes, and radioactive tracers
  • Assessment of SLN status: cytology, histopathology, and molecular assays
  • Clinical and biological significance of micrometastasis and isolated tumor cells in axillary lymph nodes
  • Biological process involving the dissemination of breast tumor cells to the lymph nodes
  • The effect of tumor heterogeneity on breast cancer metastasis
  • Role of the microenvironment in the dissemination and growth of breast tumor cells in a distant (secondary) site
  • Identification of biomarkers and predisposing factors associated with axillary lymph node metastasis
  • Comparison of the molecular alterations in primary tumors and lymph node metastasis and its clinical applications (potentials and limitations)
  • New targets and clinical therapies for metastatic breast cancer

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijbc/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 304697
  • - Editorial

Breast Axillary Lymph Node Metastasis

Luciane R. Cavalli | Rachel E. Ellsworth | ... | Giuseppe Viale
  • Special Issue
  • - Volume 2011
  • - Article ID 867152
  • - Research Article

Lymphangiogenesis and Axillary Lymph Node Metastases Correlated with VEGF-C Expression in Two Immunocompetent Mouse Mammary Carcinoma Models

Yuko Ito | Masa-Aki Shibata | ... | Yoshinori Otsuki
  • Special Issue
  • - Volume 2011
  • - Article ID 870263
  • - Research Article

Evaluation of Sentinel Node Biopsy in Locally Advanced Breast Cancer Patients Who Become Clinically Node-Negative after Neoadjuvant Chemotherapy: A Preliminary Study

Shaji Thomas | Apurva Prakash | ... | Monisha Choudhury
  • Special Issue
  • - Volume 2011
  • - Article ID 873987
  • - Research Article

Patterns of Cellular Distribution with the Sentinel Node Positive for Breast Cancer

Ekaterini Tsiapali | Marcia M. Schmidt | ... | Jennifer Gass
  • Special Issue
  • - Volume 2011
  • - Article ID 195892
  • - Review Article

Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?

Anastasia Pazaiti | Ian S. Fentiman
  • Special Issue
  • - Volume 2011
  • - Article ID 420981
  • - Review Article

CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis

David Hiller | Quyen D. Chu
  • Special Issue
  • - Volume 2011
  • - Article ID 973245
  • - Research Article

Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer?

Kenneth D. Westover | M. Brandon Westover | ... | Rinaa S. Punglia
  • Special Issue
  • - Volume 2011
  • - Article ID 142763
  • - Research Article

Differential Gene Expression in Primary Breast Tumors Associated with Lymph Node Metastasis

Rachel E. Ellsworth | Lori A. Field | ... | Craig D. Shriver
International Journal of Breast Cancer
 Journal metrics
Acceptance rate12%
Submission to final decision45 days
Acceptance to publication35 days
CiteScore3.300
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.