International Journal of Breast Cancer

Innovations in Personalized and Targeted Therapies for Breast Cancer


Status
Published

1East Carolina University, Greenville, USA

2Cleveland Clinic, Cleveland, USA

3University of Colorado Cancer Center, Denver, USA

4University of Alabama at Birmingham, Birmingham, USA


Innovations in Personalized and Targeted Therapies for Breast Cancer

Description

An explosion of research insight into the biology of breast cancer in recent years has revealed a large variety of heterogeneous molecular pathways defining prognosis and affecting response to therapy and clinical outcomes. Molecular targeting now informs all treatment modalities, including surgery, radiation, and systemic therapies. Personalized therapies are under study and in clinical use for the entire range of locoregional and systemic therapies and are increasingly informed by genomic and proteomic assays, functional imaging, quality of life, and patient preferences. Outcomes are so favorable in biologically low risk breast cancer that current research is studying how to reduce overtreatment through more limited surgery abbreviated or omitted courses of radiation and gene assays to predict the benefit of systemic therapies. On the other end of the spectrum, aggressive molecular subtypes, in particular those in the basal/triple negative category, are the subject of intensification of targeted therapies. The ultimate vision for each individual patient with a newly diagnosed breast cancer will involve a panel of gene assays that will predict the benefit of surgery, radiation, and systemic therapy based on the unique biology of the individual cancer.

This special issue will focus on the innovations in targeted breast cancer therapies helping to advance the science towards the goal of truly personalized medicine. We invite investigators to contribute original research articles as well as review articles describing this exciting area of research and treatment advancements. We are particularly interested in articles describing translational science ready for clinical trials or recent clinical trials that have successfully defined areas of personalized medicine in breast cancer treatment.

Potential topics include but are not limited to the following:

  • Clinical or translational studies of reducing therapy in breast cancers with low risk molecular profiles
  • Genomics-based drug development and clinical trials for breast cancer subtypes
  • Role of modifier genes in cancer prognosis and response to therapy
  • Using gene profiles to direct local therapies
  • Using functional imaging to define target volumes for surgery or radiation
  • Emerging targeted systemic therapies for Her2+, triple negative, and estrogen-positive subtypes
  • Immunotherapy
  • Gene therapy
  • Clinical trial design

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5409846
  • - Editorial

Innovations in Personalized and Targeted Therapies for Breast Cancer

Eleanor E. R. Harris | Jennifer De Los Santos | ... | Stephen R. Grobmyer
  • Special Issue
  • - Volume 2018
  • - Article ID 6729802
  • - Review Article

Personalizing Radiation Treatment Delivery in the Management of Breast Cancer

Kamran A. Ahmed | G. Daniel Grass | ... | Roberto Diaz
  • Special Issue
  • - Volume 2018
  • - Article ID 4786819
  • - Review Article

The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent

Jessica M. S. Jutzy | Jeffrey M. Lemons | ... | Steven J. Chmura
  • Special Issue
  • - Volume 2018
  • - Article ID 4809183
  • - Review Article

Precision Medicine for Breast Cancer: The Paths to Truly Individualized Diagnosis and Treatment

Eleanor E. R. Harris
  • Special Issue
  • - Volume 2018
  • - Article ID 1402824
  • - Review Article

Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation?

Ashlyn S. Everett | Drexell Hunter Boggs | Jennifer F. De Los Santos
  • Special Issue
  • - Volume 2018
  • - Article ID 2734820
  • - Review Article

Establishing the Role of Stereotactic Ablative Body Radiotherapy in Early-Stage Breast Cancer

Aisling Barry | Anthony Fyles
  • Special Issue
  • - Volume 2017
  • - Article ID 1683060
  • - Review Article

Metronomic Chemotherapy in Triple-Negative Metastatic Breast Cancer: The Future Is Now?

M. E. Cazzaniga | L. Cortesi | ... | E. Rulli
  • Special Issue
  • - Volume 2017
  • - Article ID 4279724
  • - Review Article

Molecular Signatures of Radiation Response in Breast Cancer: Towards Personalized Decision-Making in Radiation Treatment

Corey Speers | Lori J. Pierce
  • Special Issue
  • - Volume 2017
  • - Article ID 1403054
  • - Research Article

The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis

Raja Alyusuf | Javed Fayyaz Wazir | ... | Moiz Bakhiet
  • Special Issue
  • - Volume 2017
  • - Article ID 6395712
  • - Research Article

Are Patients Traveling for Intraoperative Radiation Therapy?

Kelsey E. Larson | Stephanie A. Valente | ... | Stephen R. Grobmyer
International Journal of Breast Cancer
 Journal metrics
Acceptance rate12%
Submission to final decision45 days
Acceptance to publication35 days
CiteScore3.300
Impact Factor-
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