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International Journal of Biomedical Imaging
Volume 2006, Article ID 20164, 11 pages

The Application of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in the Diagnosis and Therapy of Acute Cerebral Infarction

1Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
2Associated Laboratory, Beijing Tiantan Hospital, Beijing 100050, China
3Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, P.O. Box 2728, Beijing 100080, China
4Department of Neurology, Shougang Hospital, Beijing University, Beijing 100041, China

Received 4 January 2006; Revised 2 July 2006; Accepted 18 July 2006

Academic Editor: Lizhi Sun

Copyright © 2006 Ying Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diffusion- and perfusion-weighted magnetic resonance imaging (DWI and PWI) was applied for stroke diagnose in 120 acute (<48 h) ischemic stroke patients. At hyperacute (<6 h) stage, it is difficult to find out the infarction zone in conventional T1 or T2 image, but it is easy in DWI, apparent diffusion coefficient (ADC) map; when at 3–6-hour stage it is also easy in PWI, cerebral blood flow (CBF) map, cerebral blood volume (CBV) map, and mean transit time (MTT) map; at acute (6–48 h) stage, DWI or PWI is more sensitive than conventional T1 or T2 image too. Combining DWI with ADC, acute and chronic infarction can be distinguished. Besides, penumbra which should be developed in meaning was used as an indication or to evaluate the therapeutic efficacy. There were two cases (<1.5 h) that broke the model of penumbra because abnormity was found in DWI but not that in PWI, finally they recovered without any sequela.