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International Journal of Biomedical Imaging
Volume 2007, Article ID 63234, 4 pages
http://dx.doi.org/10.1155/2007/63234
Research Article

Kidney Modelling for FDG Excretion with PET

1Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
2Department of Nuclear Medicine, General Hospital of PLA, Beijing 100853, China

Received 18 January 2007; Accepted 31 May 2007

Academic Editor: Jie Tian

Copyright © 2007 Huiting Qiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to detect the physiological process of FDG's filtration from blood to urine and to establish a mathematical model to describe the process. Dynamic positron emission tomography scan for FDG was performed on seven normal volunteers. The filtration process in kidney can be seen in the sequential images of each study. Variational distribution of FDG in kidney can be detected in dynamic data. According to the structure and function, kidney is divided into parenchyma and pelvis. A unidirectional three-compartment model is proposed to describe the renal function in FDG excretion. The time-activity curves that were picked up from the parenchyma, pelvis, and abdominal aorta were used to estimate the parameter of the model. The output of the model has fitted well with the original curve from dynamic data.