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International Journal of Biomedical Imaging
Volume 2007, Article ID 86741, 4 pages
Research Article

Experimental Study on Bioluminescence Tomography with Multimodality Fusion

1Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, P.O. Box 2728, Beijing 100080, China
2Life Science Center, Xidian University, Xian, Shaanxi 710071, China
3Division of Biomedical Imaging, VT-WFU School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA

Received 12 March 2007; Accepted 1 August 2007

Academic Editor: Ming Jiang

Copyright © 2007 Yujie Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To verify the influence of a priori information on the nonuniqueness problem of bioluminescence tomography (BLT), the multimodality imaging fusion based BLT experiment is performed by multiview noncontact detection mode, which incorporates the anatomical information obtained by the microCT scanner and the background optical properties based on diffuse reflectance measurements. In the reconstruction procedure, the utilization of adaptive finite element methods (FEMs) and a priori permissible source region refines the reconstructed results and improves numerical robustness and efficiency. The comparison between the absence and employment of a priori information shows that multimodality imaging fusion is essential to quantitative BLT reconstruction.