Experimental Study on Bioluminescence Tomography with Multimodality Fusion

Lv, Yujie; Tian, Jie; Cong, Wenxiang; Wang, Ge

doi:https://doi.org/10.1155/2007/86741

International Journal of Biomedical Imaging

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Recent Advances in Molecular Imaging

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Research Article | Open Access

Volume 2007 | Article ID 086741 | https://doi.org/10.1155/2007/86741

Experimental Study on Bioluminescence Tomography with Multimodality Fusion

Yujie Lv,¹Jie Tian,^1,2Wenxiang Cong,³and Ge Wang³

Academic Editor: Ming Jiang

Received12 Mar 2007

Accepted01 Aug 2007

Published10 Sept 2007

Abstract

To verify the influence of a priori information on the nonuniqueness problem of bioluminescence tomography (BLT), the multimodality imaging fusion based BLT experiment is performed by multiview noncontact detection mode, which incorporates the anatomical information obtained by the microCT scanner and the background optical properties based on diffuse reflectance measurements. In the reconstruction procedure, the utilization of adaptive finite element methods (FEMs) and a priori permissible source region refines the reconstructed results and improves numerical robustness and efficiency. The comparison between the absence and employment of a priori information shows that multimodality imaging fusion is essential to quantitative BLT reconstruction.

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Copyright

Copyright © 2007 Yujie Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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