Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study

Figure 2

(a) The PET experimental protocol consisted of 6 randomly presented sessions (baseline, hypercapnia, and 4 levels of visual stimulation). A tracer bolus injection was given at the start of each block. (b) Each run has a 3-minute acquisition period divided in 12 5-second, 6 10-second, and 3 20-second frames, followed by 15 minutes of rest. (c) A volume of activity distribution was acquired during each frame. (d) This series of distribution images and the blood activity curve were fit into a kinetic model, resulting in a CBF map.