Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study

Table 1

CBF measured with PET in 10 subjects under 6 experimental conditions (baseline, 4 levels of graded visual checkerboard (CHB) stimulation as well as hypercapnia (HC)) in the V1 ROI, followed by the CBF measurements averaged over the 10 subjects in all 3 ROIs—V1, t-map, and GM ROIs. The PET ΔCBF measurements have a high standard deviation, largely attributable to the abnormally high CBF measured in subject 8.

Subject	Baseline	25% CHB	50% CHB	75% CHB	100% CHB	5% HC
mean CBF in V1 ROI for all 10 subjects (mL/100 g tissue/min)
1	47.7	62.5	50.5	49.0	61.3	46.8
2	34.6	54.4	53.4	43.1	52.4	38.1
3	32.6	58.3	42.6	48.6	55.9	39.8
4	42.4	50.4	55.3	45.1	52.0	60.2
5	36.8	51.6	63.0	39.6	43.4	38.4
6	39.5	46.4	74.7	59.6	62.6	50.7
7	62.5	72.5	62.9	64.3	68.6	65.0
8	114.3	139.5	137.8	164.3	148.7	115.9
9	66.1	80.2	53.6	66.65	76.4	66.6
10	50.0	36.6	45.4	37.1	31.8	35.1
Average mean ± std CBF in VI ROI
	52.6±24.4	65.2±28.9	63.9±27.6	61.7±37.4	65.3±31.9	55.6±24.1
Average mean ±std CBF in t-map ROI
	53.6±24.5	70.6±27.9	71.3±27.0	68.9±37.6	73.8±30.2	60.0±23.2
Average mean ± std CBF in GM ROI
	47.0±22.3	52.8±23.2	51.7±20.4	50.3±26.8	52.8±23.9	49.8±21.0