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International Journal of Biomedical Imaging
Volume 2008, Article ID 672582, 7 pages
Review Article

The Role of Noninvasive Techniques in Stroke Therapy

1Institute of Biotechnology University of Cambridge, Tennis Court Road, Cambridge CB2 3HU, UK
2Department of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
3Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Street, Montreal, Quebec, Canada H3W 1W5

Received 3 May 2007; Accepted 25 September 2007

Academic Editor: Oury Monchi

Copyright © 2008 Daniel Maxwell Bernad and Julien Doyon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Noninvasive techniques such as functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) have provided insight into understanding how neural connections are altered in consequence to cerebrovascular injury. The first part of this review will briefly survey some of the methodological issues and limitations related to noninvasive poststroke motor recovery studies. The second section will investigate some of the different neural mechanisms that underlie neurorehabilitation in stroke patients. The third part will explore our current understanding of motor memory processing, describe the neural structures that subserve motor memory consolidation, and discuss the current literature related to memory reconsolidation in healthy adults. Lastly, this paper will suggest the potential therapeutic applications of integrating noninvasive tools with memory consolidation and reconsolidation theories to enhance motor recovery. The overall objective of this work is to demonstrate how noninvasive technologies have been utilized in the multidisciplinary field of clinical behavioral neuroscience and to highlight their potential to be employed as clinical tools to promote individualized motor recovery in stroke patients.