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International Journal of Biomedical Imaging
Volume 2009, Article ID 108028, 13 pages
Research Article

Low-Noise Dynamic Reconstruction for X-Ray Tomographic Perfusion Studies Using Low Sampling Rates

1Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Im Neuenheimer Feld 368, 69120 Heidelberg, Germany
2Siemens AG Healthcare Sector, P.O. Box 1266, 91294 Forchheim, Germany

Received 11 December 2008; Revised 24 July 2009; Accepted 20 October 2009

Academic Editor: Carl Crawford

Copyright © 2009 Pau Montes and Günter Lauritsch. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Functional imaging based on tomographic X-ray imaging relies on the reconstruction of a temporal sequence of images which accurately reproduces the time attenuation curves of the tissue. The main constraints of these techniques are temporal resolution and dose. Using current techniques the data acquisition has to be performed fast so that the dynamic attenuation values can be regarded as static during the scan. Due to the relatively high number of repeated scans the dose per single scan has to be low yielding a poor signal-to-noise ratio (SNR) in the reconstructed images. In a previous publication a temporal interpolation scheme in the projection data space was relaxing the temporal resolution constraint. The aim of this contribution is the improvement of the SNR. A temporal smoothing term is introduced in the temporal interpolation scheme such that only the physiologic relevant bandwidth is considered. A significant increase of the SNR is achieved. The obtained level of noise only depends on the total dose applied and is independent of the number of scans and the SNR of a single reconstructed image. The approach might be the first step towards using slowly rotating CT systems for perfusion imaging like C-arm or small animal CT scanners.