Imaging Multidimensional Therapeutically Relevant Circadian Relationships

Figure 2

Snapshot of Supplementary Movie 2. WEE-1 is known to prevent or gate mitosis at the G₂M interface of the cell cycle. VEGF is known to promote cancer growth and cancer cell division. Throughout the day as WEE-1 increases, no mitosis occurs. As WEE-1 decreases, mitosis appears and gradually increases to a high level. Concurrently, VEGF content of the same tumor cell increases markedly.

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