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International Journal of Biomedical Imaging
Volume 2009, Article ID 946271, 7 pages
Research Article

Implementation and Application of PSF-Based EPI Distortion Correction to High Field Animal Imaging

1Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, 79106 Freiburg, Germany
2Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
3Bruker Biospin, Ettlingen, Germany
4Research Center Magnetic Resonance Bavaria e.V (MRB), 97074 Würzburg, Germany

Received 10 March 2009; Revised 8 August 2009; Accepted 9 October 2009

Academic Editor: J. C. Chen

Copyright © 2009 Dominik Paul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this work is to demonstrate the functionality and performance of a PSF-based geometric distortion correction for high-field functional animal EPI. The EPI method was extended to measure the PSF and a postprocessing chain was implemented in Matlab for offline distortion correction. The correction procedure was applied to phantom and in vivo imaging of mice and rats at 9.4T using different SE-EPI and DWI-EPI protocols. Results show the significant improvement in image quality for single- and multishot EPI. Using a reduced FOV in the PSF encoding direction clearly reduced the acquisition time for PSF data by an acceleration factor of 2 or 4, without affecting the correction quality.