Hybrid ICA-Seed-Based Methods for fMRI Functional Connectivity Assessment: A Feasibility Study

Table 8

Experiment 5: mean percentages of thresholded task-related GLM maps that are covered by the thresholded subject-specific FC maps generated with each hybrid method below. The right-most column gives percentages after adjusting the z-score used to threshold the FC maps so that number of false positives equals number of false negatives. The results are similar to those from Experiment 3, with DRA covering less of the task-related maps than the SV, FV, MV, and DRS methods.

Method of Generating Maps	Group ICA Source	Percent of Task-Related Map Covered (95% Confidence Interval)
		Before Threshold Adjustment	After Threshold Adjustment
Single-voxel seed (SV)	PICA	54 (44–63)	62 (52–71)
9-voxel ROI seed (FV)	PICA	58 (48–68)	63 (53–72)
40-voxel ROI seed (MV)	PICA	62 (52–72)	64 (54–74)
Dual regression, 1 spatial map (DRS)	PICA	76 (68–85)	69 (61–78)
Dual regression, all spatial maps (DRA)	PICA	12 (7–16)	43 (36–50)