Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography
The hybrid MRI-DOT system. (a) Schematic of the DOT system. The system utilizes 6 laser diodes (LD 1–6). Only LD2 (785 nm) is used for DCE-DOT studies. The lasers are modulated at 100 MHz by the network analyzer. The optical signals are collected by detector fibers prior to transmission to the detection system, which uses PMTs as detectors. After downconverting to 1 kHz, signals are recorded simultaneously by a data acquisition card (DAQ). (b) The fiber optic interface. Eight sources and eight detectors are placed in fan-beam geometry. A 16-leg birdcage RF coil is integrated into the interface. When placed in the MRI bore, both optical and MR measurements can be acquired simultaneously.