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Figure 3: Comparison between regular DOT and DCE-DOT. Column 1: MR images of all the phantoms. Columns 2 and 4: regular endogenous DOT reconstruction for the contrasts B2 and B8, respectively. At B2 contrast, regular DOT cannot resolve the inclusion accurately, and the images are also contaminated by the background noise significantly. Even though all of the inclusions can be located when contrast is high, artifacts are still present in the regular DOT image. Columns 3 and 5: DCE-DOT reconstruction for contrast B2 (B2–B0) and B8 (B8–B2), respectively. The inclusions are clearly identified for both low and high contrast. This shows the superiority of DCE-DOT.