Table of Contents Author Guidelines Submit a Manuscript
International Journal of Biomedical Imaging
Volume 2012, Article ID 509783, 11 pages
http://dx.doi.org/10.1155/2012/509783
Research Article

Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA

Received 4 January 2012; Accepted 13 April 2012

Academic Editor: Richard H. Bayford

Copyright © 2012 Roberto Reif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Liew, P. Mitchell, E. Rochtchina et al., “Fractal analysis of retinal microvasculature and coronary heart disease mortality,” European Heart Journal, vol. 32, no. 4, pp. 422–429, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Y. Wong, R. Klein, A. R. Sharrett et al., “Retinal arteriolar narrowing and risk of coronary heart disease in men and women: the Atherosclerosis Risk in Communities Study,” JAMA, vol. 287, no. 9, pp. 1153–1159, 2002. View at Google Scholar · View at Scopus
  3. N. Cheung, G. Liew, R. I. Lindley et al., “Retinal fractals and acute lacunar stroke,” Annals of Neurology, vol. 68, no. 1, pp. 107–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Kumar, C. A. Staton, S. S. Cross, M. W. R. Reed, and N. J. Brown, “Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds,” British Journal of Surgery, vol. 96, no. 12, pp. 1484–1491, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000. View at Google Scholar · View at Scopus
  6. L. Wang, H. Fan, Z. Y. Zhang et al., “Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells,” Biomaterials, vol. 31, no. 36, pp. 9452–9461, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Grinvald, E. Lieke, and R. D. Frostig, “Functional architecture of cortex revealed by optical imaging of intrinsic signals,” Nature, vol. 324, no. 6095, pp. 361–364, 1986. View at Google Scholar · View at Scopus
  8. A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” Journal of Cerebral Blood Flow and Metabolism, vol. 21, no. 3, pp. 195–201, 2001. View at Google Scholar · View at Scopus
  9. A. N. Nielsen, M. Fabricius, and M. Lauritzen, “Scanning laser-Doppler flowmetry of rat cerebral circulation during cortical spreading depression,” Journal of Vascular Research, vol. 37, no. 6, pp. 513–522, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Misgeld and M. Kerschensteiner, “In vivo imaging of the diseased nervous system,” Nature Reviews Neuroscience, vol. 7, no. 6, pp. 449–463, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Zhang, K. Maslov, and L. V. Wang, “Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo,” Optics Letters, vol. 35, no. 19, pp. 3195–3197, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Optics Letters, vol. 36, no. 7, pp. 1134–1136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Optics Express, vol. 15, no. 7, pp. 4083–4097, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. K. Wang and S. Hurst, “Mapping of cerebro-vascular blood perfusion in mice with skin and skull intact by Optical Micro-AngioGraphy at 1.3μm wavelength,” Optics Express, vol. 15, no. 18, pp. 11402–11412, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Li, L. An, R. Reif, T. T. Shen, M. Johnstone, and R. K. Wang, “In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography,” Biomedical Optics Express, vol. 2, no. 11, pp. 3109–3118, 2011. View at Google Scholar
  16. L. An, T. T. Shen, and R. K. Wang, “Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina,” Journal of Biomedical Optics, vol. 16, no. 10, Article ID 106013, 6013. View at Google Scholar
  17. J. Qin, J. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers in Surgery and Medicine, vol. 43, no. 2, pp. 122–129, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Jia, P. Li, and R. K. Wang, “Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in mice,” Journal of Biomedical Optics, vol. 16, no. 9, Article ID 096019, 2011. View at Publisher · View at Google Scholar
  19. Z. Zhi, Y. Jung, Y. Jia, L. An, and R. K. Wang, “High sensitive volumetric imaging of renal microcirculation in vivo using Ultrahigh Sensitive Optical Microangiography,” Biomedical Optics Express, vol. 2, no. 5, pp. 1059–1068, 2011. View at Google Scholar
  20. Y. Zhou, K. G. Sheets, E. J. Knott et al., “Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse,” Experimental Eye Research, vol. 93, no. 5, pp. 636–648, 2011. View at Publisher · View at Google Scholar
  21. D. Goldenberg, U. Soiberman, A. Loewenstein, and M. Goldstein, “Heidelberg spectral-domain optical coherence tomographic findings in retinal artery macroaneurysm,” Retina, vol. 32, no. 5, pp. 990–995, 2012. View at Publisher · View at Google Scholar
  22. Y. K. Tao, K. M. Kennedy, and J. A. Izatt, “Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography,” Optics Express, vol. 17, no. 5, pp. 4177–4188, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. J. W. Baish, T. Stylianopoulos, R. M. Lanning et al., “Scaling rules for diffusive drug delivery in tumor and normal tissues,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 5, pp. 1799–1803, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying Physiologic, Pathologic and Tumor Angiogenesis,” PLoS ONE, vol. 6, no. 6, Article ID e20807, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. P. W. Huang and C. H. Lee, “Automatic classification for pathological prostate images based on fractal analysis,” IEEE Transactions on Medical Imaging, vol. 28, no. 7, pp. 1037–1050, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Havlin, S. V. Buldyrev, A. L. Goldberger et al., “Fractals in biology and medicine,” Chaos, Solitons and Fractals, vol. 6, no. C, pp. 171–201, 1995. View at Google Scholar · View at Scopus
  27. T. J. Macgillivray, N. Patton, F. N. Doubal, C. Graham, and J. M. Wardlaw, “Fractal analysis of the retinal vascular network in fundus images,” IEEE Engineering in Medicine and Biology Society, vol. 2007, pp. 6456–6459, 2007. View at Google Scholar · View at Scopus
  28. M. Zamir, “Fractal dimensions and multifractility in vascular branching,” Journal of Theoretical Biology, vol. 212, no. 2, pp. 183–190, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. H. W. Chung and Y. H. Huang, “Fractal analysis of nuclear medicine images for the diagnosis of pulmonary emphysema: interpretations, implications, and limitations,” American Journal of Roentgenology, vol. 174, no. 4, pp. 1055–1059, 2000. View at Google Scholar · View at Scopus
  30. R. K. Wang, “Modelling optical properties of soft tissue by fractal distribution of scatterers,” Journal of Modern Optics, vol. 47, no. 1, pp. 103–120, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Schmoll, A. S. G. Singh, C. Blatter et al., “Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension,” Biomedical Optics Express, vol. 2, no. 5, pp. 1159–1168, 2011. View at Google Scholar
  32. D. P. Popescu, C. Flueraru, Y. Mao, S. Chang, and M. G. Sowa, “Signal attenuation and box-counting fractal analysis of optical coherence tomography images of arterial tissue,” Biomedical Optics Express, vol. 1, no. 1, pp. 268–277, 2010. View at Google Scholar
  33. L. An, J. Qin, and R. K. Wang, “Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds,” Optics Express, vol. 18, no. 8, pp. 8220–8228, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Attali and A. Montanvert, “Computing and Simplifying 2D and 3D Continuous Skeletons,” Computer Vision and Image Understanding, vol. 67, no. 3, pp. 261–273, 1997. View at Google Scholar · View at Scopus
  35. B. R. Masters, “Fractal analysis of the vascular tree in the human retina,” Annual Review of Biomedical Engineering, vol. 6, pp. 427–452, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Parsons-Wingerter, B. Lwai, M. C. Yang et al., “A novel assay of angiogenesis in the quail chorioallantoic membrane: stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection,” Microvascular Research, vol. 55, no. 3, pp. 201–214, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. B. B. Mandelbrot, The Fractal Geometry of Nature, W.H. Freeman, 1983.
  38. V. Guarino, L. Ambrosio, A. Guaccio, and P. A. Netti, “Image processing and fractal box counting: user-assisted method for multi-scale porous scaffold characterization,” Journal of Materials Science, vol. 21, no. 12, pp. 3109–3118, 2010. View at Publisher · View at Google Scholar · View at Scopus