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International Journal of Biomedical Imaging
Volume 2013, Article ID 989624, 7 pages
Research Article

Corneal Sublayers Thickness Estimation Obtained by High-Resolution FD-OCT

1Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Turin, Italy
2TIMA Laboratory (Grenoble INP, UJF, CNRS), 46 avenue Félix Viallet, 38031 Grenoble, France

Received 5 March 2013; Accepted 21 May 2013

Academic Editor: Michael W. Vannier

Copyright © 2013 Diego Alberto and Roberto Garello. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper presents a novel processing technique which can be applied to corneal in vivo images obtained with optical coherence tomograms across the central meridian of the cornea. The method allows to estimate the thickness of the corneal sublayers (Epithelium, Bowman’s layer, Stroma, Endothelium, and whole corneal thickness) at any location, including the center and the midperiphery, on both nasal and temporal sides. The analysis is carried out on both the pixel and subpixel scales to reduce the uncertainty in thickness estimations. This technique allows quick and noninvasive assessment of patients. As an example of application and validation, we present the results obtained from the analysis of 52 healthy subjects, each with 3 scans per eye, for a total of more than 300 images. Particular attention has been paid to the statistical interpretation of the obtained results to find a representative assessment of each sublayer’s thickness.