Insight into the Molecular Imaging of Alzheimer’s Disease

Table 1

List of radiotracers designed for the PET as well as SPECT based analysis of AD pathophysiology.

Radiotracer		Emission	Modality	Specificity	Condition
^11C-PIB	20 minutes	Positron	PET	Aβ	AD
^11C-AZD2184	20 minutes	Positron	PET	Aβ	AD
^18F-FDDNP	110 minutes	Positron	PET	Aβ and Tau	AD
^18F-AV-45	110 minutes	Positron	PET	Aβ	AD
^18F-BAY94-9172	110 minutes	Positron	PET	Aβ	AD
^18F-GE067	110 minutes	Positron	PET	Aβ	AD
^18F-AZD4694	110 minutes	Positron	PET	Aβ	AD
^11C-BF-227	20 minutes	Positron	PET	Aβ	AD
^11C-SB-13	20 minutes	Positron	PET	Aβ	AD
^123I-SB-13	13.2 hours	Gamma	SPECT	Aβ	AD
^18F-THK523	110 minutes	Positron	PET	Tau	Tauopathies
^18F-THK5105	110 minutes	Positron	PET	Tau	Tauopathies
^18F-THK5107	110 minutes	Positron	PET	Tau	Tauopathies
^18F-T807	110 minutes	Positron	PET	Tau	Tauopathies
^18F-T808	110 minutes	Positron	PET	Tau	Tauopathies
^11C-PBB3	20 minutes	Positron	PET	Tau	Tauopathies
^11C-PK11195	20 minutes	Positron	PET	PBR-TSPO	Neuroinflammation
^123I-PK11195	13.2 hours	Gamma	SPECT	PBR-TSPO	Neuroinflammation
^11C-DPA713	20 minutes	Positron	PET	PBR-TSPO	Neuroinflammation
^11C-CLINME	20 minutes	Positron	PET	PBR-TSPO	Neuroinflammation
^18F-DPA714	110 minutes	Positron	PET	PBR-TSPO	Neuroinflammation
^18F-PBR111	110 minutes	Positron	PET	PBR-TSPO	Neuroinflammation
^123I-CLINDE	13.2 hours	Gamma	SPECT	PBR-TSPO	Neuroinflammation
^11C-DED	20 minutes	Positron	PET	I2BS	Neuroinflammation
^11C-FTIMD	20 minutes	Positron	PET	I2BS	Neuroinflammation
^11C-AA	20 minutes	Positron	PET	AA analogue	Lipid metabolism
^11C-DHA	20 minutes	Positron	PET	DHA analogue	Lipid metabolism
^11C-Enzastaurin	20 minutes	Positron	PET	PKC	Neuroprotection
^11C-MeDAS	20 minutes	Positron	PET	Myelin	Neuroprotection
^124I-pQHNIG70	4.18 days	Positron	PET	HSF-1/HSP-70	Neuroprotection
^11C-Verapamil	20 minutes	Positron	PET	P-gp	Neuroprotection