Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions

Figure 7

Normalized average raw intensity profiles ((a) and (c)) and enhanced signal tracks ((b) and (d)) of a single platelet ((a) and (b)) and a platelet aggregate ((c) and (d)). The platelet signal, significantly weaker than the aggregate one, is ~10 μm in diameter, while the aggregate one is ~40 μm. Both the single platelet and the aggregate are visualized using Indo-1.