Classification of Alzheimer’s and MCI Patients from Semantically Parcelled PET Images: A Comparison between AV45 and FDG-PET

Table 4

Classification performance in whole-brain approaches (SVM, PCA, RBF, and RF), evaluating accuracy (ACC), sensitivity (SEN), specificity (SPE), and area under the curve (AUC). (a) AD versus NC; (b) AD versus EMCI; (c) AD versus LMCI; (d) EMCI versus LMCI.

(a)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	83.3	81.4	87.9	0.843
	1st + 2nd visit	89.2	83.2	92.4	0.934
PCA	1st visit	75.0	74.7	78.1	0.796
	1st + 2nd visit	76.7	75.2	79.9	0.814
RBF	1st visit	68.3	66.5	75.3	0.756
	1st + 2nd visit	78.3	80.9	70.4	0.852
RF	1st visit	85.0	88.4	79.7	0.911
	1st + 2nd visit	87.7	90.2	81.4	0.924

(b)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	80.0	84.5	78.9	0.857
	1st + 2nd visit	82.0	86.1	79.7	0.871
PCA	1st visit	68.3	65.2	70.0	0.743
	1st + 2nd visit	78.8	80.7	68.4	0.808
RBF	1st visit	62.7	64.1	59.3	0.676
	1st + 2nd visit	89.2	91.8	86.2	0.934
RF	1st visit	80.4	84.2	77.6	0.855
	1st + 2nd visit	82.4	86.3	79.5	0.876

(c)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	66.0	68.3	59.9	0.713
	1st + 2nd visit	64.7	69.4	61.3	0.698
PCA	1st visit	64.0	67.0	61.2	0.692
	1st + 2nd visit	65.0	68.1	62.0	0.708
RBF	1st visit	67.9	70.4	66.4	0.735
	1st + 2nd visit	66.0	69.3	64.2	0.739
RF	1st visit	82.1	85.6	80.1	0.875
	1st + 2nd visit	81.7	84.5	79.1	0.888

(d)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	51.7	54.5	57.8	0.594
	1st + 2nd visit	55.0	58.2	63.9	0.643
PCA	1st visit	60.9	65.6	59.1	0.663
	1st + 2nd visit	65.7	70.8	64.0	0.712
RBF	1st visit	65.0	68.1	62.5	0.704
	1st + 2nd visit	68.2	71.5	65.7	0.801
RF	1st visit	72.5	79.0	68.7	0.785
	1st + 2nd visit	72.5	79.2	69.9	0.790