Comparison of Diffusion Tensor Imaging Metrics in Normal-Appearing White Matter to Cerebrovascular Lesions and Correlation with Cerebrovascular Disease Risk Factors and Severity

Table 2

Values of the four major DTI metrics measured in the 10 global cerebral tissues/lesions considered in this study using the DTI processing pipeline. Mean, coefficient of variation (CV), and 95% confidence interval (CI) of the DTI metrics in each lesion were calculated across the ONDRI CVD subjects who have that specific tissue/lesion. Note that the first two rows provide the number and percentage of the subjects from the ONDRI CVD cohort (152 subjects in total) who have each type of these tissues/lesions. If the volume of a lesion within a subject’s brain is smaller than 24 mm³, we assumed that the subject does not have that specific lesion type.

Tissue type		NAWM	dWMH	pWMH	PVS	NAGM	Stroke	pLACN	vCSF	dLACN	sCSF
# of subjects		152	145	152	116	152	86	85	152	56	152
% of subjects		100	95	100	76	100	57	56	100	37	100
FA	Mean	0.38	0.27	0.26	0.16	0.16	0.15	0.13	0.12	0.12	0.07
	CV	0.07	0.21	0.20	0.18	0.08	0.30	0.28	0.12	0.28	0.14
	95% CI	0.004	0.01	0.008	0.005	0.002	0.01	0.008	0.002	0.009	0.002
MD	Mean (mm^2/s)	0.79	1.14	1.28	1.58	1.09	1.64	1.83	2.74	1.93	2.15
	CV	0.05	0.12	0.10	0.10	0.06	0.19	0.13	0.05	0.13	0.07
	95% CI (mm^2/s)	0.006	0.023	0.021	0.03	0.011	0.066	0.053	0.02	0.069	0.023
AD	Mean (mm^2/s)	1.13	1.47	1.63	1.85	1.25	1.86	2.07	3.07	2.16	2.30
	CV	0.04	0.09	0.08	0.09	0.06	0.16	0.12	0.04	0.11	0.07
	95% CI (mm^2/s)	0.007	0.021	0.02	0.03	0.012	0.064	0.052	0.022	0.065	0.025
RD	Mean (mm^2/s)	0.62	0.98	1.11	1.45	1.02	1.53	1.71	2.58	1.82	2.08
	CV	0.07	0.16	0.13	0.11	0.06	0.21	0.15	0.05	0.15	0.07
	95% CI (mm^2/s)	0.007	0.026	0.023	0.03	0.011	0.068	0.055	0.02	0.071	0.023