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International Journal of Biomaterials
Volume 2010 (2010), Article ID 691452, 14 pages
http://dx.doi.org/10.1155/2010/691452
Research Article

Polymeric-Calcium Phosphate Cement Composites-Material Properties: In Vitro and In Vivo Investigations

1Department Oral Biology, Medical College of Georgia, Augusta, GA 30912-1129, USA
2Department Orthopedic Surgery, Medical College of Georgia, Augusta, GA 30912-1129, USA
3Department of Dental Materials, Misr University, 11787 Cairo, Egypt
4Department of Oral Pathology, Cairo University, 11559 Cairo, Egypt
5Department of Oral Pathology, Misr University, 11787 Cairo, Egypt
6Department of Dental Materials, Medical College of Georgia, Augusta, GA 30912-1129, USA

Received 17 December 2009; Revised 1 May 2010; Accepted 9 June 2010

Academic Editor: Tadashi Kokubo

Copyright © 2010 Rania M. Khashaba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

New polymeric calcium phosphate cement composites (CPCs) were developed. Cement powder consisting of 60 wt% tetracalcium phosphate, 30 wt% dicalcium phosphate dihydrate, and 10 wt% tricalcium phosphate was combined with either 35% w/w poly methyl vinyl ether maleic acid or polyacrylic acid to obtain CPC-1 and CPC-2. The setting time and compressive and diametral tensile strength of the CPCs were evaluated and compared with that of a commercial hydroxyapatite cement. In vitro cytotoxicity and in vivo biocompatibility of the two CPCs and hydroxyapatite cement were assessed. The setting time of the cements was 5–15 min. CPC-1 and CPC-2 showed significantly higher compressive and diametral strength values compared to hydroxyapatite cement. CPC-1 and CPC-2 were equivalent to Teflon controls after 1 week. CPC-1, CPC-2, and hydroxyapatite cement elicited a moderate to intense inflammatory reaction at 7 days which decreased over time. CPC-1 and CPC-2 show promise for orthopedic applications.