Review Article

The Blood Compatibilities of Blood Purification Membranes and Other Materials Developed in Japan

Figure 9

The mechanism of bradykinin-induced anaphylactic shock. When the blood contacts with a negatively charged material, it results in production of Bradykinin (BK) having vasodilating action. The bioactivity of this BK is inactivated by kininase II which is an enzyme identical to ACE. Therefore, the function of kininase II which is an enzyme identical to ACE is inhibited by taking ACE inhibitor and it causes increase in BK concentration in the blood, vasodilatation, and shock symptom being unable to inactivate BK.
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