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International Journal of Biomaterials
Volume 2012, Article ID 279167, 7 pages
Research Article

Bone Morphometric Evaluation around Immediately Placed Implants Covered with Porcine-Derived Pericardium Membrane: An Experimental Study in Dogs

1Department of Prosthodontics, Faculty of Odontology, Malmö University, 205 06 Malmö, Sweden
2Department of Dentistry, UNIGRANRIO, Brazil
3Department of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA
4Department of Prosthodontics, Tufts University School of Dental Medicine, Boston, MA 0211, USA
5Departments of Biomaterials & Biomimetics and Periodontology & Implant Dentistry, New York University College of Dentistry, New York, NY 10010, USA
6Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA 0211, USA

Received 24 June 2012; Accepted 24 October 2012

Academic Editor: Carlos Nelson Elias

Copyright © 2012 Ryo Jimbo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate whether porcine-derived bioresorbable pericardium membrane coverage enhances the osseointegration around implants placed in fresh extraction sockets. Study Design. Twenty-four commercially available endosseous implants were placed in the fresh extraction sockets of the mandibular first molar of mature beagles ( ). On one side, implants and osteotomy sites were covered with porcine-derived bioresorbable pericardium membranes, whereas on the other side, no membranes were used. After 6 weeks, samples were retrieved and were histologically processed for histomorphometric analysis. Results. The histological observation showed that bone loss and soft tissue migration in the coronal region of the implant were evident for the control group, whereas bone fill was evident up to the neck of the implant for the membrane-covered group. Bone-to-implant contact was significantly higher for the membrane-covered group compared to the control group, 75% and 45% ( ), respectively. Conclusion. The experimental membranes proved to regenerate bone around implants placed in fresh extraction sockets without soft tissue intrusion.