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International Journal of Biomaterials
Volume 2012, Article ID 345029, 10 pages
Research Article

Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds

Bio-Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Saitama, Kawagoe 350-8585, Japan

Received 12 May 2011; Accepted 4 November 2011

Academic Editor: Narayana Garimella

Copyright © 2012 Brahatheeswaran Dhandayuthapani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Design of blood compatible surfaces is required to minimize platelet surface interactions and increase the thromboresistance of foreign surfaces when they are used as biomaterials especially for artificial blood prostheses. In this study, single wall carbon nanotubes (SWCNTs) and Zein fibrous nanocomposite scaffolds were fabricated by electrospinning and evaluated its antithrombogenicity and hydrophilicity. The uniform and highly smooth nanofibers of Zein composited with different SWCNTs content (ranging from 0.2 wt% to 1 wt%) were successfully prepared by electrospinning method without the occurrence of bead defects. The resulting fiber diameters were in the range of 100–300 nm without any beads. Composite nanofibers with and without SWCNT were characterized through a variety of methods including scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and tensile mechanical testing. The water uptake and retention ability of composite scaffolds decreased whereas thermal stability increased with an addition of SWCNTs. Hemolytic property and platelet adhesion ability of the nanocomposite (Zein-SWCNTs) were explored. These observations suggest that the novel Zein-SWCNTs composite scaffolds may possibly hold great promises as useful antithrombotic material and promising biomaterials for tissue engineering application.