Table of Contents Author Guidelines Submit a Manuscript
International Journal of Biomaterials
Volume 2012, Article ID 345029, 10 pages
http://dx.doi.org/10.1155/2012/345029
Research Article

Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds

Bio-Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Saitama, Kawagoe 350-8585, Japan

Received 12 May 2011; Accepted 4 November 2011

Academic Editor: Narayana Garimella

Copyright © 2012 Brahatheeswaran Dhandayuthapani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. B. Gorbet and M. V. Sefton, “Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes,” Biomaterials, vol. 25, no. 26, pp. 5681–5703, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. A. P. McGuigan and M. V. Sefton, “The influence of biomaterials on endothelial cell thrombogenicity,” Biomaterials, vol. 28, no. 16, pp. 2547–2571, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. J. H. Lee, H. B. Lee, and J. D. Andrade, “Blood compatibility of polyethylene oxide surfaces,” Progress in Polymer Science, vol. 20, no. 6, pp. 1043–1079, 1995. View at Google Scholar · View at Scopus
  4. R. P. Lanza, R. Langer, and W. L. Chick, Principles of Tissue Engineering, Academic Press, New York, NY, USA, 1996.
  5. W. H. Park, L. Jeong, D. I. Yoo, and S. Hudson, “Effect of chitosan on morphology and conformation of electrospun silk fibroin nanofibers,” Polymer, vol. 45, no. 21, pp. 7151–7157, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. M. Huang, Y. Z. Zhang, M. Kotaki, and S. Ramakrishna, “A review on polymer nanofibers by electrospinning and their applications in nanocomposites,” Composites Science and Technology, vol. 63, no. 15, pp. 2223–2253, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Dong, Q. Sun, and J. Y. Wang, “Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility,” Biomaterials, vol. 25, no. 19, pp. 4691–4697, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. Gao, P. Ding, L. Zhang et al., “Study of a Pingyangmycin delivery system: Zein/Zein-SAIB in situ gels,” International Journal of Pharmaceutics, vol. 328, no. 1, pp. 57–64, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. H. J. Wang, Z. X. Lin, X. M. Liu, S. Y. Sheng, and J. Y. Wang, “Heparin-loaded zein microsphere film and hemocompatibility,” Journal of Controlled Release, vol. 105, no. 1-2, pp. 120–131, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Liu, Q. Sun, H. Wang, L. Zhang, and J. Y. Wang, “Microspheres of corn protein, zein, for an ivermectin drug delivery system,” Biomaterials, vol. 26, no. 1, pp. 109–115, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Mecitoǧlu, A. Yemenicioǧlu, A. Arslanoǧlu, Z. S. Elmaci, F. Korel, and A. E. Çetin, “Incorporation of partially purified hen egg white lysozyme into zein films for antimicrobial food packaging,” Food Research International, vol. 39, no. 1, pp. 12–21, 2006. View at Publisher · View at Google Scholar
  12. S. Gong, H. Wang, Q. Sun, S. T. Xue, and J. Y. Wang, “Mechanical properties and in vitro biocompatibility of porous zein scaffolds,” Biomaterials, vol. 27, no. 20, pp. 3793–3799, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. E. W. Wong, P. E. Sheehan, and C. M. Lieber, “Nanobeam mechanics: elasticity, strength, and toughness of nanorods and nanotubes,” Science, vol. 277, no. 5334, pp. 1971–1975, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Bianco and M. Prato, “Can carbon nanotubes be considered useful tools for biological applications?” Advanced Materials, vol. 15, no. 20, pp. 1765–1768, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Che, B. B. Lakshmi, E. R. Fisher, and C. R. Martin, “Carbon nanotubule membranes for electrochemical energy storage and production,” Nature, vol. 393, no. 6683, pp. 346–349, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Frank, P. Poncharal, Z. L. Wang, and W. A. De Heer, “Carbon nanotube quantum resistors,” Science, vol. 280, no. 5370, pp. 1744–1746, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. J. M. Planeix, N. Coustel, B. Coq et al., “Application of carbon nanotubes as supports in heterogeneous catalysis,” Journal of the American Chemical Society, vol. 116, pp. 7935–7936, 1994. View at Google Scholar
  18. M. Panhuis, “Vaccine delivery by carbon nanotubes,” Chemistry and Biology, vol. 10, no. 10, pp. 897–898, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. S. K. Smart, A. I. Cassady, G. Q. Lu, and D. J. Martin, “The biocompatibility of carbon nanotubes,” Carbon, vol. 44, no. 6, pp. 1034–1047, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. K. J. Gilmore, S. E. Moulton, and G. G. Wallace, “Incorporation of carbon nanotubes into the biomedical polymer poly(styrene-β-isobutylene-β-styrene),” Carbon, vol. 45, no. 2, pp. 402–410, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. B. S. Harrison and A. Atala, “Carbon nanotube applications for tissue engineering,” Biomaterials, vol. 28, no. 2, pp. 344–353, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Singh, D. Pantarotto, L. Lacerda et al., “Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 9, pp. 3357–3362, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. X. L. Xie, Y. W. Mai, and X. P. Zhou, “Dispersion and alignment of carbon nanotubes in polymer matrix: a review,” Materials Science and Engineering R, vol. 49, no. 4, pp. 89–112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Mazinani, A. Ajji, and C. Dubois, “Morphology, structure and properties of conductive PS/CNT nanocomposite electrospun mat,” Polymer, vol. 50, no. 14, pp. 3329–3342, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. K. K. H. Wong, M. Zinke-Allmang, J. L. Hutter, S. Hrapovic, J. H. T. Luong, and W. Wan, “The effect of carbon nanotube aspect ratio and loading on the elastic modulus of electrospun poly(vinyl alcohol)-carbon nanotube hybrid fibers,” Carbon, vol. 47, no. 11, pp. 2571–2578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. Thomassin, X. Lou, C. Pagnoulle et al., “Multiwalled carbon nanotube/poly(ε-caprolactone) nanocomposites with exceptional electromagnetic interference shielding properties,” Journal of Physical Chemistry C, vol. 111, no. 30, pp. 11186–11192, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Zhang, M. A. Kandadai, J. Cech, S. Roth, and S. A. Curran, “Poly(L-lactide) (PLLA)/multiwalled carbon nanotube (MWCNT) composite: characterization and biocompatibility evaluation,” Journal of Physical Chemistry B, vol. 110, no. 26, pp. 12910–12915, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. X. Zhang, J. Zhang, and Z. Liu, “Conducting polymer/carbon nanotube composite films made by in situ electropolymerization using an ionic surfactant as the supporting electrolyte,” Carbon, vol. 43, no. 10, pp. 2186–2191, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. L. J. Suggs, R. S. Krishnan, C. A. Garcia, S. J. Peter, J. M. Anderson, and A. G. Mikos, “In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels,” Journal of Biomedical Materials Research, vol. 42, no. 2, pp. 312–320, 1998. View at Google Scholar · View at Scopus
  30. A. P. Pêgo, B. Siebum, M. J. A. Van Luyn et al., “Preparation of degradable porous structures based on 1,3-trimethylene carbonate and D,L-lactide (Co)polymers for heart tissue engineering,” Tissue Engineering, vol. 9, no. 5, pp. 981–994, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. C. L. Cummings, D. Gawlitta, R. M. Nerem, and J. P. Stegemann, “Properties of engineered vascular constructs made from collagen, fibrin, and collagen-fibrin mixtures,” Biomaterials, vol. 25, no. 17, pp. 3699–3706, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Chen, T. Sato, T. Ushida et al., “The use of a novel PLGA fiber/collagen composite web as a scaffold for engineering of articular cartilage tissue with adjustable thickness,” Journal of Biomedical Materials Research, vol. 67, no. 4, pp. 1170–1180, 2003. View at Google Scholar · View at Scopus
  33. F. Balavoine, P. Schultz, C. Richard, V. Mallouh, T. W. Ebbesen, and C. Mioskowski, “Helical crystallization of proteins on carbon nanotubes: a first step towards the development of new biosensors,” Angewandte Chemie, vol. 38, no. 13-14, pp. 1912–1915, 1999. View at Google Scholar · View at Scopus
  34. P. R. Supronowicz, P. M. Ajayan, K. R. Ullmann, B. P. Arulanandam, D. W. Metzger, and R. Bizios, “Novel current-conducting composite substrates for exposing osteoblasts to alternating current stimulation,” Journal of Biomedical Materials Research, vol. 59, no. 3, pp. 499–506, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. T. J. Webster, M. C. Waid, J. L. McKenzie, R. L. Price, and J. U. Ejiofor, “Nano-biotechnology: carbon nanofibres as improved neural and orthopaedic implants,” Nanotechnology, vol. 15, no. 1, pp. 48–54, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Meng, H. Kong, H. Y. Xu, L. Song, C. Y. Wang, and S. S. Xie, “Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery,” Journal of Biomedical Materials Research, vol. 74, no. 2, pp. 208–214, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Sun, H. Tan, D. Han, Q. Fu, and L. Jiang, “No platelet can adhere-largely improved blood compatibility on nanostructured superhydrophobic surfaces,” Small, vol. 1, no. 10, pp. 959–963, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Wang, Z. Tan, X. Liu et al., “Conducting MWNT/poly(vinyl acetate) composite nanofibres by electrospinning,” Nanotechnology, vol. 17, no. 23, article 019, pp. 5829–5835, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. K. Saeed, S. Y. Park, H. J. Lee, J. B. Baek, and W. S. Huh, “Preparation of electrospun nanofibers of carbon nanotube/polycaprolactone nanocomposite,” Polymer, vol. 47, no. 23, pp. 8019–8025, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. Biological Evaluation of Medical Devices—Part 4: Selection of Tests for Interactions with Blood, ISO 10993-4, 2nd edition, 2002.
  41. H. Lam, Electrospinning of single wall carbon nanotube reinforced aligned fibrils and yarns, Ph.D. thesis, Drexel University, 2004.
  42. J. Ayutsede, M. Gandhi, S. Sukiraga et al., “Carbon nanotube reinforced Bombyx mori silk nanofibers by the electrospinning process,” Biomacromolecules, vol. 7, no. 1, pp. 208–214, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Dror, W. Salalha, R. L. Khalfin, Y. Cohen, A. L. Yarin, and E. Zussman, “Carbon nanotubes embedded in oriented polymer nanofibers by electrospinning,” Langmuir, vol. 19, no. 17, pp. 7012–7020, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. M. B. Bazbouz and G. K. Stylios, “Novel mechanism for spinning continuous twisted composite nanofiber yarns,” European Polymer Journal, vol. 44, no. 1, pp. 1–12, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. M. T. Hunley, P. Pötschke, and T. E. Long, “Melt dispersion and electrospinning of non-functionalized multiwalled carbon nanotubes in thermoplastic polyurethane,” Macromolecular Rapid Communications, vol. 30, no. 24, pp. 2102–2106, 2009. View at Publisher · View at Google Scholar
  46. F. Du, J. E. Fischer, and K. I. Winey, “Coagulation method for preparing single-walled carbon nanotube/poly(methyl methacrylate) composites and their modulus, electrical conductivity, and thermal stability,” Journal of Polymer Science, Part B, vol. 41, no. 24, pp. 3333–3338, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Moniruzzaman, J. Chattopadhyay, W. E. Billups, and K. I. Winey, “Tuning the mechanical properties of SWNT/nylon 6,10 composites with flexible spacers at the interface,” Nano Letters, vol. 7, no. 5, pp. 1178–1185, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. J. P. Vacanti and R. Langer, “Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation,” The Lancet, vol. 354, no. 1, pp. 32–34, 1999. View at Google Scholar · View at Scopus
  49. M. Peter, P. T. Sudheesh Kumar, N. S. Binulal, S. V. Nair, H. Tamura, and R. Jayakumar, “Development of novel α-chitin/nanobioactive glass ceramic composite scaffolds for tissue engineering applications,” Carbohydrate Polymers, vol. 78, no. 4, pp. 926–931, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. A. G. Mikos, G. Sarakinos, M. D. Lyman, D. E. Ingber, J. P. Vacanti, and R. Langer, “Prevascularization of porous biodegradable polymers,” Biotechnology and Bioengineering, vol. 42, no. 6, pp. 716–723, 1993. View at Google Scholar
  51. V. I. Sevastianov, “Interrelation of protein adsorption and blood compatibility of biomaterials,” in High Performance Biomaterials: A Comprehensive Guide to Medical and Pharmaceutical Applications, M. Szycher, Ed., pp. 245–256, Technomic, Lancaster, UK, 1991. View at Google Scholar
  52. J. Autian, “Polymers in medicine and surgery,” in Polymer Science and Technology, R. L. Kronenthal, Z. Oser, and E. Martin, Eds., pp. 181–203, Plenum, New York, NY, USA, 1975. View at Google Scholar
  53. J. H. Lee, Y. M. Ju, W. K. Lee, K. D. Park, and Y. H. Kim, “Platelet adhesion onto segmented polyurethane surfaces modified by PEO- And sulfonated PEO-containing block copolymer additives,” Journal of Biomedical Materials Research, vol. 40, no. 2, pp. 314–323, 1998. View at Google Scholar · View at Scopus
  54. J. M. Grunkemeier, W. B. Tsai, and T. A. Horbett, “Co-adsorbed fibrinogen and von Willebrand factor augment platelet procoagulant activity and spreading,” Journal of Biomaterials Science, Polymer Edition, vol. 12, no. 1, pp. 1–20, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. J. H. Lee, H. W. Jung, I. K. Kang, and H. B. Lee, “Cell behaviour on polymer surfaces with different functional groups,” Biomaterials, vol. 15, no. 9, pp. 705–711, 1994. View at Publisher · View at Google Scholar · View at Scopus