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International Journal of Biomaterials
Volume 2012, Article ID 538061, 9 pages
Review Article

Antibiotic-Impregnated Bone Grafts in Orthopaedic and Trauma Surgery: A Systematic Review of the Literature

Klinik für Orthopädie und Orthopädische Chirurgie, Universitätskliniken des Saarlandes, Kirrbergerstraße 1D, Saar, 66421 Homburg, Germany

Received 23 March 2012; Accepted 6 June 2012

Academic Editor: Sanjukta Deb

Copyright © 2012 Konstantinos Anagnostakos and Katrin Schröder. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There exist several options for local antibiotic therapy in orthopaedic and trauma surgery. Over the past years, the use of antibiotic-impregnated bone grafts (AIBGs) has become a popular procedure in the treatment of bone and joint infections. A major advantage of AIBGs involves the possibility of impregnation of various antibiotics depending on the sensitivity profile of the causative organism, whereas an additional surgery with removal of the antibiotic carrier is not necessary, as in the use of antibiotic-loaded bone cement. However, generalized conclusions cannot be clearly drawn from the existing literature due to differences of bone used, impregnation method, antibiotics, their doses, laboratory circumstances, or clinical indications. The present work reviews the literature regarding this topic and sheds some light onto the choice of bone and antibiotics, manufacturing details, and clinical experience.