Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions: Application in Thrombogenicity Testing of Different Materials for Vascular Applications

Table 1

Activation markers in plasma after Chandler loop, roller pump and Hemobile blood circulation at 25 mL/min.

	Baseline	Chandler	Roller pump	Hemobile
TxB2 (pg/mL)	34±12	712±296	1222^∗±166	879±167
TAT (μg/mL)	3.2±1.7	66.7±21.5	65.4±24.4	64.3±20.6
Hemolysis (gHb/L)	0.07±0.06	0.21±0.19	0.85^∗∗±0.14	0.21±0.06
Platelet adhesion	—	0.46^#±0.41	0.72±0.42	0.89±0.53

^∗𝑃<0.05, ^∗∗𝑃<0.01 compared to Chandler loop and Hemobile; ^#𝑃<0.05 compared to roller pump and Hemobile
TXB2: tromboxane B2; TAT: thrombin-antithrombin III.