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International Journal of Biomaterials
Volume 2012 (2012), Article ID 851264, 9 pages
Research Article

Dimensional Ridge Preservation with a Novel Highly Porous TiO 2 Scaffold: An Experimental Study in Minipigs

Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, PO Box 1109, Blindern, 0317 Oslo, Norway

Received 11 May 2012; Accepted 3 September 2012

Academic Editor: Frank Feyerabend

Copyright © 2012 Hanna Tiainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite being considered noncritical size defects, extraction sockets often require the use of bone grafts or bone graft substitutes in order to facilitate a stable implant site with an aesthetically pleasing mucosal architecture and prosthetic reconstruction. In the present study, the effect of novel TiO2 scaffolds on dimensional ridge preservation was evaluated following their placement into surgically modified extraction sockets in the premolar region of minipig mandibles. After six weeks of healing, the scaffolds were wellintegrated in the alveolar bone, and the convex shape of the alveolar crest was preserved. The scaffolds were found to partially preserve the dimensions of the native buccal and lingual bone walls adjacent to the defect site. A tendency towards more pronounced vertical ridge resorption, particularly in the buccal bone wall of the nongrafted alveoli, indicates that the TiO2 scaffold may be used for suppressing the loss of bone that normally follows tooth extraction.