Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs
Figure 5
BMP2-transduced microencapsulated MSCs bone formation in a mouse model for heterotopic ossification. 3 × 106 ovine B MSCs transduced with 15,000 vp/cell were injected into the hind limb of a NOD/SCID mouse. The resulting heterotopic ossification was observed by X-ray and MicroCT for (a) and (b) for freshly prepared BMP2 microencapsulated MSCs and (d) and (e) for cryopreserved BMP2 microencapsulated MSCs. (c) The volume of the resulting heterotopic ossification was not different between the two groups.
