Figure 3: Characterization of collagen remodeling. Representative day 1 and day 28 images of PriMatrix implant and overlying dermis following trichrome (a) and picrosirius red staining (b), illustrating an increased density and organization of implants over time. (c) Representative high power images of immunofluorescence bovine collagen staining at days 1 and 28, demonstrating the persistence of PriMatrix derived fibers during the remodeling process. Scale bar is 100 μm for all images. BVC: bovine collagen; DAPI: nuclear stain.