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International Journal of Biomaterials
Volume 2014, Article ID 157952, 7 pages
Research Article

Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier

1Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil
2Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil
3Physics Department, Faculty of Sciences, São Paulo State University, 14-01 Engenheiro Luiz Edmundo Carrijo Coube Avenue, 17033-360 Bauru, SP, Brazil

Received 28 July 2014; Revised 26 October 2014; Accepted 10 November 2014; Published 22 December 2014

Academic Editor: Ravin Narain

Copyright © 2014 Heitor Dias Murbach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.