Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats

Table 3

Biochemical values of rats when exposed to HANPs (mean ± SD, ).

Parameters	Control	HANPs
		(25 mg/kg)	(50 mg/kg)	(100 mg/kg)
Glucose	110.8 ± 35.47	88.6 ± 13.81	91.6 ± 15.78	91.2 ± 14.46
Cholesterol	60.2 ± 6.06	59.4 ± 4.56	63.0 ± 5.48	57.6 ± 5.73
Triglycerides	106.0 ± 18.37	122.0 ± 0.65	123.0 ± 0.65	112.6 ± 0.62
Bilirubin	0.18 ± 0.10	0.13 ± 0.04	0.09 ± 0.01	0.12 ± 0.044
Albumin	4.08 ± 0.32	4.36 ± 0.27	4.40 ± 0.25	4.14 ± 0.25
Calcium	10.68 ± 0.50	10.92 ± 0.38	10.68 ± 0.24	10.46 ± 0.47
Phosphate	9.05 ± 2.23	8.13 ± 1.71	7.94 ± 1.94	8.86 ± 1.83
Chlorides	108.6 ± 2.43	106.5 ± 1.65	104.1 ± 0.99	109.5 ± 1.65
Total proteins	7.56 ± 0.27	7.54 ± 0.21	7.54 ± 0.41	7.52 ± 0.51
Creatinine	0.95 ± 0.09	0.86 ± 0.06	0.87 ± 0.07	0.89 ± 0.08
Urea	37.1 ± 2.62	38.6 ± 2.93	37.8 ± 3.30	38.4 ± 3.30
SGPT	132.2 ± 28.54	151.9 ± 34.61	107.5 ± 13.26	113.1 ± 21.82
SGOT	188.7 ± 79.28	123.2 ± 20.65	127.7 ± 8.62	153.0 ± 36.23
ALP	170.8 ± 24.01	195.4 ± 28.11	206.8 ± 38.52	204.6 ± 19.28
GGT	8.28 ± 9.11	2.52 ± 1.74	4.34 ± 7.16	1.38 ± 0.29

Statistically significant ; HANPs: hydroxyapatite nanoparticles.