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International Journal of Biomaterials
Volume 2014, Article ID 924278, 7 pages
http://dx.doi.org/10.1155/2014/924278
Research Article

Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon

1Department of Pharmaceutics, Oriental College of Pharmacy, Sector 2, Sanpada, Navi Mumbai 400 705, India
2Department of Radiology, Seth GS Medical College and KEM Hospital, Mumbai 400 012, India

Received 9 February 2014; Revised 14 June 2014; Accepted 15 June 2014; Published 2 July 2014

Academic Editor: Bruce Milthorpe

Copyright © 2014 Kishor Butte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The higher incidences of side effects of existing drugs have shifted researchers and clinicians to explore the dietary phytoconstituents for its therapeutic potentials. The present study is based on compression coated curcumin tablet for the colon. Curcumin has anti-inflammatory and antioxidant properties. Curcumin presents a bioavailability problem due to poor solubility. An inclusion complex was formed with hydroxypropyl-β-cyclodextrin to enhance the solubility. In this study, the core tablet of curcumin inclusion complex was compressed between the layers of polymer blend of pectin and Eudragit S100. The 32 full factorial design was utilised for optimization of the formulation. The polymer ratio (X1) and coat thickness (X2) presented significant effects on the selected responses, i.e., percent drug release after 4 hours (Y240) and difference in percent drug release between 4th and 6th hour () in presence of pectinase enzyme. The results revealed that higher coat weight (600 mg) and higher level of pectin ratio (70% w/w) protected the curcumin tablet till ascending colon. The in vivo studies by roentgenography method using human volunteers supported these observations. Hence, it can be concluded that the combination of pectin and Eudrgit S100 makes the system biodegradable and pH dependent for targeting the drug to the colon.