Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment

Table 1

Parameters used in different sets of experiments. The “bold” values show the parameters, which were changed in their respective recipes.

Studied parameters	w1/o/w2 double emulsion’s parameter
	PLGA (mg)	w1 (mL)	Acetone (mL)	PVA (% w/v)	w2 (mL)	Speed (rpm)
PLGA amount used						8,000
						8,000
						8,000
						8,000
w1 volume						8,000
						8,000
						8,000
						8,000
Acetone volume			Control			8,000
						8,000
						8,000
						8,000
						8,000
PVA concentration						8,000
						8,000
						8,000
						8,000
w2 volume						8,000
						8,000
						8,000
						8,000
Stirring speed for the 1st emulsion						8,000
						12,000
						18,000