Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models

Figure 1

Cell survival, morphology, and growth status on polymeric scaffolds. (a) Main procedures of preparing PLGA-coated slides and 3D porous PLGA scaffolds. (b) Examination of MDA-MB-231 cell survival on PLGA-coated slides ((b)(i) and (b)(ii)) and porous PLGA scaffolds ((b)(iii) and (b)(iv)) using live and dead assays. Scale bars, 100 m. The number of live and dead cells in the 2D and 3D cultures were quantified in ((b)(v)). (c) Proliferation rate of MCF10A and MDA-MB-231 cells on PLGA-coated slides. (d) Proliferation rate of MCF10A and MDA-MB-231 cells on porous PLGA scaffolds. , .